Resting State Cortical Electroencephalographic Rhythms and White Matter Vascular Lesions in Subjects with Alzheimer's Disease: An Italian Multicenter Study
Resting State Cortical Electroencephalographic Rhythms and White Matter Vascular Lesions in Subjects with Alzheimer's Disease: An Italian Multicenter Study
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DOI：
10.3233/jad-2011-101710
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发表时间：
2011-01-01
影响因子：
4
通讯作者：
Frisoni, Giovanni B.
中科院分区：
文献类型：
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作者：
Babiloni, Claudio;Lizio, Roberta;Frisoni, Giovanni B.
在遗忘型轻度认知障碍(MCI)受试者中，静息状态脑电(EEG)节律不会随着脑白质血管病变的增加而恶化[1]，尽管脑白质在阿尔茨海默病(AD)过程中会受损。在这里，我们测试了即使在AD受试者中是否也是如此。本文记录了40例健康老年人(Nold)、96例遗忘性MCI和83例AD患者的闭眼静息状态脑电数据。脑白质血管病变通过记录在MCI和AD受试者中的磁共振成像进行指标化(约42%的病例遵循ADNI标准)。MCI受试者根据白质病变的中位数分为两个亚组，即MCI+(血管负荷最高的人，n=48)和MCI-(血管负荷最低的人，n=48)。AD受试者(AD+，n=42；AD-，n=41)也是如此。感兴趣的脑电节律有增量(2-4赫兹)、β(4-8赫兹)、α1(8-10.5赫兹)、阿尔法2(10.5-13赫兹)、贝塔1(13-20赫兹)、贝塔2(20-30赫兹)和伽马(30-40赫兹)。Loreta软件估计了皮质脑电波来源。与NOD组相比，MCI组和AD组表现出众所周知的增量源和α源异常。此外，MCI+组枕叶、颞叶和边缘α1源的波幅均高于MCI-组。AD+组枕叶三角区波幅低于AD-组，这是一个新发现。此外，AD+组的中枢、顶叶、枕叶、颞叶和边缘α源的波幅均高于AD-组。这些来源的幅度与整体认知状态(即简易精神状态评估得分)相关。这些结果表明，在健忘性MCI和AD患者中，静息状态的后三角洲和αEEG节律不会随着白质血管病变的增加而恶化。这些节律可能对阿尔茨海默病的神经退化过程和认知状态更敏感，而不是对白质伴发的损害更敏感。
Resting state electroencephalographic (EEG) rhythms do not deteriorate with the increase of white matter vascular lesion in amnesic mild cognitive impairment (MCI) subjects [1], although white matter is impaired along Alzheimer's disease (AD). Here we tested whether this is true even in AD subjects. Closed-eye resting state EEG data were recorded in 40 healthy elderly (Nold), 96 amnesic MCI, and 83 AD subjects. White matter vascular lesions were indexed by magnetic resonance imaging recorded in the MCI and AD subjects (about 42% of cases following ADNI standards). The MCI subjects were divided into two sub-groups based on the median of the white matter lesion, namely MCI+(people with highest vascular load; n = 48) and MCI-(people with lowest vascular load; n = 48). The same was true for the AD subjects (AD+, n = 42; AD-, n = 41). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), beta2 (20-30 Hz), and gamma (30-40 Hz). LORETA software estimated cortical EEG sources. When compared to Nold group, MCI and AD groups showed well known abnormalities of delta and alpha sources. Furthermore, amplitude of occipital, temporal, and limbic alpha 1 sources were higher in MCI+ than MCI-group. As a novelty, amplitude of occipital delta sources was lower in AD+ than AD-group. Furthermore, central, parietal, occipital, temporal, and limbic alpha sources were higher in amplitude in AD+ than AD-group. Amplitude of these sources was correlated to global cognitive status (i.e., Mini Mental State Evaluation score). These results suggest that in amnesic MCI and AD subjects, resting state posterior delta and alpha EEG rhythms do not deteriorate with the increase of white-matter vascular lesion. These rhythms might be more sensitive to AD neurodegenerative processes and cognitive status rather than to concomitant lesions to white matter.