A comparison of lymphocyte migration through intestinal lymph nodes, subcutaneous lymph nodes, and chronic inflammatory sites of sheep
A comparison of lymphocyte migration through intestinal lymph nodes, subcutaneous lymph nodes, and chronic inflammatory sites of sheep
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绵羊肠道淋巴结、皮下淋巴结及慢性炎症部位淋巴细胞迁移的比较
DOI：
10.1016/0016-5085(80)90918-x
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发表时间：
1980
期刊：
影响因子：
29.4
通讯作者：
J. Hay
中科院分区：
文献类型：
--
作者：
W. Chin;J. Hay
本文研究了~（51）Cr和~（111）In标记的绵羊血淋巴细胞向各淋巴室的迁移。当淋巴细胞从淋巴中分离，放射性标记，并返回静脉注射到同一动物，观察到淋巴细胞迁移的非随机模式，这取决于标记细胞的来源。从肠（空肠，回肠，或回盲部）输出淋巴分离的淋巴细胞总是产生更大的比活性在输出肠淋巴比在输出淋巴的皮下（腘或股前）淋巴结。相反，从皮下淋巴结的传出淋巴中分离的淋巴细胞在皮下淋巴结的传出淋巴中比在肠传出淋巴中产生更大的比活性。肠传出淋巴液中自由漂浮淋巴细胞的单位重力沉降表明，淋巴液中回收的放射性是由小的再循环淋巴细胞（而非淋巴母细胞）引起的。最引人注目的例子，非随机淋巴细胞迁移的淋巴细胞迁移之间的肠道传出淋巴和通过慢性炎症部位进行比较。
The migration of51Cr- and111In-labeled lymphocytes from blood to various lymph compartments was studied in sheep. When lymphocytes were isolated from lymph, radiolabeled, and returned intravenously to the same animal, nonrandom patterns of lymphocyte migration were observed, which depended on the source of the labeled cells. Lymphocytes isolated from intestinal (jejunum, ileum, or ileocecal junction) efferent lymph always produced greater specific activity in the efferent intestinal lymph than in the efferent lymph of subcutaneous (popliteal or prefemoral) lymph nodes. Conversely, lymphocytes isolated from the efferent lymph of subcutaneous lymph nodes produced greater specific activity in the efferent lymph of subcutaneous lymph nodes than in the intestinal efferent lymph. Unit gravity sedimentation of the free-floating lymphocytes in intestinal efferent lymph demonstrated that small, recirculating lymphocytes, but not lymphoblasts, were responsible for the radioactivity recovered in lymph. The most dramatic examples of nonrandom lymphocyte migration were seen when the migration of lymphocytes was compared between the intestinal efferent lymph and through sites of chronic inflammation.