Recombinant Canine Coronaviruses in Dogs, Europe
Recombinant Canine Coronaviruses in Dogs, Europe
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DOI：
10.3201/eid1601.090726
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发表时间：
2010-01-01
影响因子：
11.8
通讯作者：
Buonavoglia, Canio
中科院分区：
文献类型：
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作者：
Decaro, Nicola;Mari, Viviana;Buonavoglia, Canio
最近在欧洲的犬中发现了与猪传染性胃肠炎病毒（TGEV）可能重组起源的冠状病毒，称为犬冠状病毒（CCoV）的新亚型（IIb）。为了评估TGEV样CCoV亚型的分布，在2001-2008年期间，我们测试了患有胃肠炎的狗的粪便样品。在1,172份样本中，493份（42.06%）为CCoV阳性。CCoV-II型218例，CCoV-I、CCoV-II型182例。大约20%的CCoV-II样本具有TGEV样亚型;检测率根据地理来源而变化。在匈牙利和希腊的样本中发现了CCoV-II感染的最高和最低流行率（分别为96.87%和3.45%）。序列分析和系统进化分析表明，CCoV-IIb株与TGEV样毒株在S蛋白基因的5'端和3'端具有同源性。
Coronaviruses of potential recombinant origin with porcine transmissible gastroenteritis virus (TGEV), referred to as a new subtype (IIb) of canine coronavirus (CCoV), were recently identified in dogs in Europe. To assess the distribution of the TGEV-Iike CCoV subtype, during 2001-2008 we tested fecal samples from dogs with gastroenteritis. Of 1,172 samples, 493 (42.06%) were positive for CCoV. CCoV-II was found in 218 samples, and CCoV-I and CCoV-II genotypes were found in 182. Approximately 20% of the samples with CCoV-II had the TGEV-Iike subtype; detection rates varied according to geographic origin. The highest and lowest rates of prevalence for CCoV-II infection were found in samples from Hungary and Greece (96.87% and 3.45%, respectively). Sequence and phylogenetic analyses showed that the CCoV-IIb strains were related to prototype TGEV-Iike strains in the 5' and the 3' ends of the spike protein gene.