Hypoglycaemic effects and inhibitory effect on intestinal disaccharidases of oat beta-glucan in streptozotocin-induced diabetic mice
Hypoglycaemic effects and inhibitory effect on intestinal disaccharidases of oat beta-glucan in streptozotocin-induced diabetic mice
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DOI：
10.1016/j.foodchem.2011.05.076
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发表时间：
2011-12-01
期刊：
影响因子：
8.8
通讯作者：
Liu, Yanqi
中科院分区：
文献类型：
--
作者：
Dong, Jilin;Cai, Fengli;Liu, Yanqi
大多数关于燕麦β-葡聚糖的生理学研究都提到了健康人和糖尿病患者的血糖和胰岛素反应的衰减。本研究的主要目的是评价燕麦β-葡聚糖对链脲佐菌素诱导的糖尿病小鼠糖代谢的影响以及对糖尿病小鼠肠道和体外肠道二磷酸腺苷酶活性的影响。同时，对肠道二硫键酶的可能调控机制进行了讨论。使用二甲双胍处理的正常和糖尿病小鼠分别作为阴性和阳性对照。结果表明，燕麦β-葡聚糖在体内外均能调节葡萄糖代谢，抑制肠道二硫键合酶活性（p < 0.01），且高剂量时作用更明显，提示燕麦β-葡聚糖能有效改善肠道内环境，是一种潜在的α-糖苷酶抑制剂。(C)2011爱思唯尔有限公司保留所有权利。
Most physiological studies on oat beta (beta)-glucan referred to attenuation of blood glucose and insulin responses in both healthy and diabetic individuals. The main purpose of this work was to evaluate the effects of oat beta-glucan on glucose metabolism in streptozotocin-induced diabetic mice and the activities of intestinal disaccharidases in the diabetic mice and in vitro. Meanwhile, the potentially regulative mechanisms on intestinal disaccharidases were discussed. Normal and diabetic mice, treated with metformin, were used as the negative and positive controls, respectively. The results indicated that oat beta-glucan could regulate the glucose metabolism and inhibit the activities of intestinal disaccharidases in vivo and in vitro (p < 0.01), especially when using a high-dose, which suggested that oat beta-glucan could effectively improve the internal environment of intestinal tract and would be a potential alpha (alpha)-glycosidase inhibitor. (C) 2011 Elsevier Ltd. All rights reserved.