Early events in spontaneous neutrophil apoptosis
Early events in spontaneous neutrophil apoptosis
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DOI：
10.1042/bst0320461
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发表时间：
2004-06-01
影响因子：
3.9
通讯作者：
Lord, JM
中科院分区：
文献类型：
--
作者：
Scheel-Toellner, D;Wang, KQ;Lord, JM
中性粒细胞是非常丰富的、寿命短的白细胞，并且它们通过凋亡的死亡对于体内平衡和炎症的消退是至关重要的，然而凋亡的触发因素仍然是一个争论的话题。线粒体膜的去极化被认为是启动中性粒细胞自发性凋亡，因为中性粒细胞逐渐失去抗凋亡蛋白Mcl-1，Bax易位并插入线粒体膜。然而，其他报告显示，caspase 8是中性粒细胞凋亡所必需的，表明DR（死亡受体）信号转导的参与。由于DR连接不是中性粒细胞凋亡所必需的，这引起了有趣的可能性，即中性粒细胞凋亡期间半胱天冬酶8的激活通过新的机制发生。在这篇文章中，我们讨论了中性粒细胞凋亡机制的现有证据，这可能在没有DR连接的情况下触发DR信号。
Neutrophils are very abundant, short-lived leucocytes and their death by apoptosis is central to homoeostasis and the resolution of inflammation, yet the trigger for apoptosis is still a topic of debate. Depolarization of the mitochondrial membrane has been supposed to initiate neutrophil spontaneous apoptosis, as neutrophils gradually lose the anti-apoptotic protein Mcl-1 and Bax translocates and inserts into the mitochondrial membrane. However, other reports show that caspase 8 is required for neutrophil apoptosis, suggesting the involvement of DR (death receptor) signalling. As DR ligation is not required for neutrophil apoptosis, this raises the intriguing possibility that activation of caspase 8 during neutrophil apoptosis occurs via a novel mechanism. in the present paper, we discuss the current evidence for mechanisms occurring in neutrophil apoptosis, which could trigger DR signalling in the absence of DR ligation.