Microalbuminuria and the metabolic syndrome and its components in the Chinese population
Microalbuminuria and the metabolic syndrome and its components in the Chinese population
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DOI：
10.1111/j.1365-2362.2007.01865.x
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发表时间：
2007-10-01
影响因子：
5.5
通讯作者：
Lin, W.-Y.
中科院分区：
文献类型：
--
作者：
Lin, C.-C.;Liu, C.-S.;Lin, W.-Y.
背景微量白蛋白尿和代谢综合征(METS)都与慢性肾脏疾病和心血管疾病有关。本研究探讨尿白蛋白/肌酐比(ACR)与蛋氨酸及其组分的关系。资料与方法2004年在台湾某大都市招募2311名40岁及以上的受试者。测定空腹血糖、尿白蛋白、尿肌酐和人体测量学指标。我们将微量白蛋白尿定义为尿ACR，范围从30到300毫克/克(-1)肌酐。METS的定义使用了美国心脏协会和国家心肺血液研究所(AHA/NHLBI)和国际糖尿病联合会(IDF)的定义。结果微量白蛋白尿组的年龄、体重指数(BMI)、腰围、血压、空腹血糖、甘油三酯、总胆固醇(TCHOL)/高密度脂蛋白胆固醇(HDLc)比值、糖尿病和高血压患病率高于正常白蛋白尿组，而HDLc低于正常白蛋白尿组。在调整了年龄和BMI后，微量白蛋白尿与蛋氨酸的个体成分有关，除了女性的中心性肥胖和男性的空腹血糖升高。在调整了年龄、BMI、吸烟和饮酒状况后，多重逻辑回归显示，无论男女，根据两种定义，微量白蛋白尿与代谢综合征密切相关。根据AHA/NHLBI和IDF的定义，男性发生甲胎蛋白尿的优势比分别为1.76(1.16~2.67)和1.73(1.06~2.83)，女性分别为2.19(1.38~3.50)和2.09(1.24~3.51)。如果受试者有微量白蛋白尿，患METS的可能性就会增加。
Background Microalbuminuria and the metabolic syndrome (MetS) have both been linked to chronic kidney disease and cardiovascular disease. This study investigated the association between urinary albumin-to-creatinine ratio (ACR) and MetS and its components.Materials and methods A total of 2311 subjects aged 40 years and over were recruited in 2004 in a metropolitan city in Taiwan. The biochemical indices, such as fasting glucose levels, urinary albumin, urinary creatinine and anthropometric indices, were measured. We defined microalbuminuria as a urinary ACR ranging from 30 to 300 mg g(-1) creatinine. MetS was defined using the American Heart Association and the National Heart, Lung and Blood Institute (AHA/NHLBI) and the International Diabetes Federation (IDF) definitions. The relationship between MetS and microalbuminuria was examined using multiple logistical regression analysis.Results Subjects with microalbuminuria had higher age, body mass index (BMI), waist circumference, blood pressure, fasting plasma glucose, triglycerides, total cholesterol (TCHOL)/high-density lipoprotein cholesterol (HDL-C) ratio, prevalence of diabetes mellitus and hypertension and lower HDL-C than subjects with normoalbuminuria. After adjusting for age and BMI, microalbuminuria was associated with the individual components of MetS, except in central obesity in women and elevated fasting glucose in men. After adjusting for age, BMI, smoking and alcohol consumption status, multiple logistical regressions revealed that microalbuminuria is strongly associated with MetS in both genders and according to both definitions. The odds ratio of having MetS using the AHA/NHLBI and IDF definition was 1.76 (1.16-2.67) and 1.73 (1.06-2.83) in men and 2.19 (1.38-3.50) and 2.09 (1.24-3.51) in women, respectively.Conclusions Microalbuminuria was strongly associated with MetS and its components. There is an increased likelihood of having MetS if subjects have microalbuminuria.