Correlations between anthracycline resistance, drug accumulation and membrane glycoprotein patterns in solid tumors of mice.
Correlations between anthracycline resistance, drug accumulation and membrane glycoprotein patterns in solid tumors of mice.
复制标题
小鼠实体瘤中蒽环类药物耐药性、药物积累和膜糖蛋白模式之间的相关性。
DOI：
10.1016/0304-3835(85)90074-6
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发表时间：
1985
期刊：
影响因子：
9.7
通讯作者：
Corbett,T
中科院分区：
文献类型：
--
作者：
Kessel,D;Corbett,T
这两种损害的药物积累和出现一个新的膜糖蛋白种类（mol.重量约180，000）通常与药物诱导的对一组天然产物的高水平抗性有关，所述天然产物包括阿霉素（ADR）和柔红霉素（DNR）。在这项研究中，我们研究了不同程度的固有或（体内）诱导阿霉素耐药的小鼠乳腺、胰腺和结肠实体瘤。在这些肿瘤中，药物蓄积受损或膜糖蛋白模式改变均与耐药性无关。这些结果表明，渗透性和糖蛋白的改变可能只与非常高的耐药性。
Both impaired drug accumulation and appearance of a new membrane glycoprotein species (mol. wt. approx. 180,000) are often associated with high levels of drug-induced resistance to a group of natural products which includes adriamycin (ADR) and daunorubicin (DNR). In this study, we examined solid murine mammary, pancreatic and colon tumors varying in degrees of inherent or (in vivo) induced adriamycin resistance. Neither impaired drug accumulation nor alterations in membrane glycoprotein patterns were correlated with drug resistance in these tumors. These results suggest that permeability and glycoprotein alterations may only be associated with very high degrees of drug resistance.