Cord blood irisin levels are positively correlated with birth weight in newborn infants.
Cord blood irisin levels are positively correlated with birth weight in newborn infants.
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DOI：
10.1016/j.metabol.2015.07.019
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发表时间：
2015-11
期刊：
影响因子：
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通讯作者：
Mantzoros CS
中科院分区：
文献类型：
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作者：
Joung KE;Park KH;Filippaios A;Dincer F;Christou H;Mantzoros CS
鸢尾素是一种新型的肌肉因子，运动后由骨骼肌分泌。鸢尾素通过将白色脂肪组织（WAT）转化为棕色脂肪组织（BAT）来调节运动相关的能量消耗。因此，鸢尾素被认为是肥胖和代谢综合征的潜在生物标志物。出生时小于胎龄（SGA）的婴儿患代谢综合征的风险增加。然而，鸢尾素在新生儿中的生理作用仍有待研究。评估脐带血鸢尾素水平与新生儿胎龄和出生体重类别的关系。对341名妊娠26至41周的新生儿进行横断面研究。采集脐带血，ELISA检测血浆中鸢尾素含量。血浆鸢尾素水平与胎龄（r=0.21, p<0.001）、出生体重z评分（r=0.18, p<0.001）呈正相关。SGA婴儿的鸢尾素含量明显低于正常胎龄婴儿（64.41 [53.87 ~ 76.76]ng/mL），高于正常胎龄婴儿（68.70 [54.78 ~ 79.09]ng/mL, p<0.01）（中位数[四分位数间距]55.38 [46.56 ~ 65.72]ng/mL）。在独立于胎龄、母亲年龄、母亲BMI和妊娠期糖尿病的多变量分析中，SGA和下鸢尾素的相关性仍然显著（p=0.03）。在单胎婴儿中，鸢尾素也与母体子痫前期呈显著负相关（p=0.01）。我们的结果支持鸢尾素可能对新生儿有生理作用的观点。我们推测，SGA婴儿中鸢尾素水平的降低可能会导致他们在以后的生活中出现追赶生长和代谢综合征。
Irisin is a novel myokine, secreted from skeletal muscle after exercise. Irisin mediates exercise-related energy expenditure by turning white adipose tissue (WAT) into brown adipose tissue (BAT). Thus, irisin is considered as a potential biomarker for obesity and metabolic syndrome. Infants born small for gestational age (SGA) have increased risk for metabolic syndrome. However, the physiologic role of irisin in neonates remains to be studied. To evaluate the association of umbilical cord blood irisin levels with gestational age and birth weight categories in neonates. A cross-sectional study of 341 newborns, from 26 to 41 weeks' gestation. We collected umbilical cord blood and analyzed plasma for irisin by ELISA. Plasma irisin levels were positively correlated with gestational age (r=0.21, p<0.001), and birth weight Z-score (r=0.18, p<0.001). SGA infants had significantly lower irisin (median [interquartile range] 55.38 [46.56 - 65.72] ng/mL) compared to appropriate for gestational age infants (64.41 [53.87 - 76.76] ng/mL) and large for gestational age infants (68.70 [54.78 - 79.09] ng/mL, p<0.01). The association between SGA and lower irisin remained significant in multivariate analysis independent of gestational age, maternal age, maternal BMI, and gestational diabetes (p=0.03). In singleton infants, irisin was also significantly negatively associated with maternal preeclampsia (p=0.01). Our results support the notion that irisin may have a physiologic role in neonates. We speculate that decreased levels of irisin in SGA infants may contribute to the development of catch up growth and metabolic syndrome later in life.