Development and investigation of a thermo-responsive cholesteryl oleyl carbonate-embedded membrane
Development and investigation of a thermo-responsive cholesteryl oleyl carbonate-embedded membrane
复制标题
DOI：
10.1016/0168-3659(96)01321-1
复制
发表时间：
1996-09
影响因子：
10.8
通讯作者：
Yih-yih Lin;Ko-Shao Chen;Shan-yang Lin
中科院分区：
文献类型：
--
作者：
Yih-yih Lin;Ko-Shao Chen;Shan-yang Lin
将胆固醇油基碳酸酯 (COC) 嵌入硝酸纤维素膜中，旨在开发具有热刺激响应的药物递送系统。通过热分析和显微傅里叶变换红外光谱差示扫描量热法（Micro FTIR-DSC）测定COC的热物理性质，以确认其热响应性质。采用真空过滤法将一定量的COC氯仿溶液通过硝酸纤维素膜过滤，制备COC包埋膜。使用 10°C 至 25°C（低于和高于 COC 的凝胶-液晶相转变温度）之间的逐步温度变化来研究 COC 嵌入膜的热响应功能。结果表明，COC吸附量随着COC使用浓度的增加而线性增加。硫酸沙丁胺醇通过 COC 包埋膜的渗透速率由硝酸纤维素膜中吸收的 COC 量控制，这可以通过扫描电子显微镜 (SEM) 的观察和接触角测量来证实。硫酸沙丁胺醇通过膜的渗透可以通过温度变化敏感地控制。这意味着COC嵌入膜可用作刺激响应控制药物输送系统的热开关膜。
Cholesteryl oleyl carbonate (COC) was embedded in a cellulose nitrate membrane for the purpose of developing a drug delivery system with a thermal stimulus response. The thermophysical properties of COC were determined by thermal analysis and microscopic Fourier transform infrared spectroscopy with differential scanning calorimetry (Micro FTIR-DSC) to confirm its thermo-responsive property. The COC-embedded membrane was prepared by filtrating a certain amount of COC chloroform solution through the cellulose nitrate membrane using a vacuum filtration method. The thermo-responsive functions of COC-embedded membranes were investigated using a step-wise temperature change between 10°C and 25°C (below and above the gel-liquid crystal phase transition temperature of COC). The results indicate that the amount of COC adsorbed increased linearly with the increase of the COC concentration used. The permeation rate of salbutamol sulfate through the COC-embedded membrane was controlled by the amount of COC absorbed in the cellulose nitrate membrane, which could be confirmed by the observations of scanning electron microscopy (SEM) and contact angle measurements. The permeation of salbutamol sulfate through the membrane could be sensitively controlled by temperature changes. This implies the COC-embedded membrane may be used as a thermally on-off switching membrane for a stimuli-response controlled drug delivery system.