The metabolic syndrome: Inflammation, diabetes mellitus, and cardiovascular disease
The metabolic syndrome: Inflammation, diabetes mellitus, and cardiovascular disease
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DOI：
10.1016/j.amjcard.2005.11.010
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发表时间：
2006-01-16
影响因子：
2.8
通讯作者：
Haffner, SM
中科院分区：
文献类型：
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作者：
Haffner, SM
越来越多的证据表明炎症是心血管疾病（CVD）的重要危险因素。炎症标志物高敏 C 反应蛋白 (hs-CRP) 水平升高与 CVD 和糖尿病风险增加相关。将 hs-CRP 添加到代谢综合征的定义中已被证明可以改善 CVD 的预测。 hs-CRP 水平升高也可能预示着代谢综合征的发生。目前代谢综合征的定义不同，心血管风险似乎根据存在的危险因素而不同。需要进一步的研究来确定一个被广泛接受的综合征标准，以最佳地预测糖尿病和心血管疾病的风险。这样的定义可能包括炎症的测量。 (c) 2006 Elsevier Inc. 保留所有权利。
There is accumulating evidence that inflammation is an important risk factor in cardiovascular disease (CVD). Elevated levels of the inflammatory marker high-sensitivity C-reactive protein (hs-CRP) are associated with increased risk for CVD, and diabetes mellitus. Adding hs-CRP to the definition of the metabolic syndrome has been shown to improve the prediction of CVD. Elevated hs-CRP levels may also be predictive of development of the metabolic syndrome. Current definitions of the metabolic syndrome differ, and cardiovascular risk appears to differ according to which component risk factors are present. Further studies are required to identify a widely accepted criterion for the syndrome that will optimally predict the risk of diabetes and CVD. It is possible that such a definition will include a measure of inflammation. (c) 2006 Elsevier Inc. All rights reserved.