A Multiscale Red Blood Cell Model with Accurate Mechanics, Rheology, and Dynamics
A Multiscale Red Blood Cell Model with Accurate Mechanics, Rheology, and Dynamics
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DOI：
10.1016/j.bpj.2010.02.002
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发表时间：
2010-05-19
影响因子：
3.4
通讯作者：
Karniadakis, George Em
中科院分区：
文献类型：
--
作者：
Fedosov, Dmitry A.;Caswell, Bruce;Karniadakis, George Em
红细胞（RBC）具有高度可变形的粘弹性膜，其表现出由特殊的弹性和弯曲性质以及由外部/内部流体和膜粘度控制的复杂流变响应和丰富的流体动力学行为。我们提出了一个多尺度RBC模型，能够预测RBC力学，流变学和动力学与实验一致。基于分析理论，建模的膜特性可以唯一地与实验建立的RBC宏观特性相关，而无需任何参数的调整。红细胞的线性和非线性弹性变形与光镊实验结果相吻合。的膜的流变学性质进行了比较与那些在光学磁扭转细胞仪，膜的热波动，蠕变，然后细胞恢复。红细胞在剪切流和Poistonille流的动力学测试对实验和理论预测，后者的适用性进行了讨论。我们的研究结果清楚地表明，一个纯粹的弹性模型的膜不能准确地代表红细胞的流变特性和动力学，因此，准确的建模的粘弹性膜是必要的。
Red blood cells (RBCs) have highly deformable viscoelastic membranes exhibiting complex rheological response and rich hydrodynamic behavior governed by special elastic and bending properties and by the external/internal fluid and membrane viscosities. We present a multiscale RBC model that is able to predict RBC mechanics, rheology, and dynamics in agreement with experiments. Based on an analytic theory, the modeled membrane properties can be uniquely related to the experimentally established RBC macroscopic properties without any adjustment of parameters. The RBC linear and nonlinear elastic deformations match those obtained in optical-tweezers experiments. The rheological properties of the membrane are compared with those obtained in optical magnetic twisting cytometry, membrane thermal fluctuations, and creep followed by cell recovery. The dynamics of RBCs in shear and Poiseuille flows is tested against experiments and theoretical predictions, and the applicability of the latter is discussed. Our findings clearly indicate that a purely elastic model for the membrane cannot accurately represent the RBC's rheological properties and its dynamics, and therefore accurate modeling of a viscoelastic membrane is necessary.