FC‐23 Feline plasma cell pododermatitis: a retrospective study of 26 cases
FC‐23 Feline plasma cell pododermatitis: a retrospective study of 26 cases
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FC-23猫浆细胞足皮炎：26例回顾性研究
DOI：
10.1111/j.1365-3164.2004.411_23.x
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
S. Lebon
中科院分区：
文献类型：
--
作者：
É. Guaguère;P. Prélaud;F. Degorce;A. Muller;T. Hubert;S. Lebon
猫浆细胞足皮炎是一种罕见的皮肤病只描述在猫。我们的目的是报告一项回顾性研究26猫浆细胞足皮炎。绝育的雄性占多数（19例），25例为家猫。诊断时的年龄为6个月至12岁。主要主诉为疼痛性跛行（22例）、状况差（2例）或过度流涎（2例）。病变主要出现在跖骨和掌骨足垫，很少出现在趾足垫。一只、两只或四只脚都有问题。临床体征包括肿胀（35个足垫）、软化（36个足垫）、剥脱（19个足垫）、溃疡（9个足垫）和肿胀（9个足垫）。两只猫出现浆细胞性口腔炎，在所有病例中均观察到一般体征。16只猫为FIV阳性，1只猫为FeLV阳性。组织学表现为浅表和深部血管周围淋巴浆细胞性皮炎（2例）、几乎纯弥漫性浆细胞性皮炎（15例，10例FIV阳性）、淋巴细胞聚集在滤泡结构中的弥漫性浆细胞性皮炎（4例，均FIV阳性）和肉芽肿性炎症（5例，1例FIV阳性）。在1例FIV阳性病例中，还观察到肾、肝和肺内的浆细胞浸润。5例患者皮损活检组织中FIV-PCR阳性。两只猫被安乐死。手术切除24只猫，1-5年无复发。猫浆细胞足皮炎可以被认为是一种具有多种原因的皮肤反应模式，FIV感染可能是一个诱发因素。
经费：自筹。
Feline plasma cell pododermatitis is a rare dermatological condition exclusively described in cats. Our objective was to report a retrospective study of 26 cats with plasma cell pododermatitis. Neutered males were overrepresented (19 cases), and 25 cases were Domestic Short-haired cats. Age at time of diagnosis was 6 months to 12 years. The primary complaint was painful lameness (22 cases), poor condition (two cases) or excessive salivation (two cases). Lesions were present primarily in the metatarsal and metacarpal footpads and rarely in the digital footpads. One, two or four feet were involved. Clinical signs included swelling (35 footpads), softening (36 footpads), exfoliation (19 footpads), ulcers (nine footpads) and abscesses (nine footpads). Two cats had plasma cell stomatitis, and general signs were observed in all cases. Sixteen cats were FIV positive and one cat was FeLV positive. Histopathological findings were characterized by a superficial and deep perivascular lymphoplasmacytic dermatitis (two cases), an almost pure diffuse plasmacytic dermatitis (15 cases, 10 FIV positive), a diffuse plasmacytic dermatitis with lymphocytes grouped in follicular structures (four cases, all FIV positive) and a granulomatous inflammation (five cases, one FIV positive). Plasmacytic infiltration was also observed in one FIV-positive case within the kidneys, liver and lungs. Five cases were positive for FIV-PCR performed from lesional skin biopsies. Two cats were euthanatized. Twenty-four cats were treated by surgical excision with no relapse for 1–5 years. Feline plasma cell pododermatitis can be considered a cutaneous reaction pattern with multiple causes, and FIV infection may be a predisposing factor.
Funding: Self-funded.