Mechanisms of long range silencing by imprinted macro non-coding RNAs.
Mechanisms of long range silencing by imprinted macro non-coding RNAs.
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DOI：
10.1016/j.gde.2012.02.005
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发表时间：
2012-06
影响因子：
4
通讯作者：
Hudson, Quanah J.
中科院分区：
文献类型：
--
作者：
Pauler, Florian M.;Barlow, Denise P.;Hudson, Quanah J.
胚胎外组织中印记基因的非编码（nc） RNA沉默为理解宏观或长链ncrna基因调控的一个未被充分研究的方面提供了一个很好的模型，即它们作为远距离顺式沉默者的作用。最近发现了许多被认为调控基因表达的长基因间ncRNAs (lincRNAs)，其中一些与疾病有关。少数显示调节蛋白质编码基因被认为是通过靶向抑制或活性染色质标记起作用。相关证据还表明，印记宏观ncrna通过靶向印记启动子的抑制性组蛋白修饰，在胎盘中引起远距离顺式沉默。然而，考虑与已发表的数据一致的其他解释是及时的，即转录本身可能导致基因在远处沉默。
Non-coding (nc) RNA silencing of imprinted genes in extra-embryonic tissues provides a good model for understanding an underexamined aspect of gene regulation by macro or long ncRNAs, that is their action as long-range cis-silencers. Numerous long intergenic ncRNAs (lincRNAs) have been recently discovered that are thought to regulate gene expression, some of which have been associated with disease. The few shown to regulate protein-coding genes are suggested to act by targeting repressive or active chromatin marks. Correlative evidence also indicates that imprinted macro ncRNAs cause long-range cis-silencing in placenta by targeting repressive histone modifications to imprinted promoters. It is timely, however, to consider alternative explanations consistent with the published data, whereby transcription alone could cause gene silencing at a distance.
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