Evaluation of ultrasound tissue damage based on changes in image echogenicity in canine kidney.
Evaluation of ultrasound tissue damage based on changes in image echogenicity in canine kidney.
复制标题
基于犬肾脏图像回声变化的超声组织损伤评估。
DOI：
10.1109/tuffc.2005.1503997
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Cain,CharlesA
中科院分区：
文献类型：
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作者：
Seo,Jongbum;Tran,BinhC;Hall,TimothyL;Fowlkes,JBrian;Abrams,GeraldD;O'Donnell,Matthew;Cain,CharlesA
由于局部气泡的产生，足够高强度的超声可以在超声图像中产生高回声区域。我们探讨这些高回声区域的时间范围和超声治疗引起的组织损伤之间的联系。量化了受超声处理的活体外置犬肾中焦点区回声增强的衰减率，并将其与组织损伤的空间范围相关。衰减半衰期，t/sub half/，定义为回声增强衰减2倍的时间，在所有情况下观察到在观察到广泛组织学损伤的空间区域中大于41 s。在测量的t/sub half/小于11 s的情况下，损伤仅限于轻微出血或未检测到。对于使用造影剂增强治疗效率的病例，这些t/sub/ discrimination边界为41 s和11 s，无统计学差异。即使造影剂输注显著降低了损伤产生的治疗脉冲持续时间阈值，情况也是如此。
Sufficiently high intensity ultrasound can create hyperechoic regions in an ultrasound image due to local bubble generation. We explore the link between the temporal extent of these hyperechoic regions and tissue damage caused by ultrasound therapy. The decay rate of increased echogenicity from the focal zone in insonated live exteriorized canine kidney was quantified and correlated to the spatial extent of tissue damage. The decay half-time, t/sub half/, defined as the time for echogenicity enhancement to decay by a factor of 2, was observed in all cases to be greater than 41 s in spatial zones in which extensive histological damage was observed. In cases in which the measured t/sub half/ was less than 11 s, the damage was limited to minor hemorrhage, or it was not detected. These t/sub half/ discrimination boundaries of 41 and 11 s were not statistically different for cases in which contrast agent was used to enhance therapeutic efficiency. This was true even though contrast agent infusion significantly reduced the therapy pulse duration threshold for damage production.