Receptors mediating adenovirus attachment and internalization
Receptors mediating adenovirus attachment and internalization
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DOI：
10.1016/s0006-2952(98)00332-3
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发表时间：
1999-05-01
影响因子：
5.8
通讯作者：
Bergelson, JM
中科院分区：
文献类型：
--
作者：
Bergelson, JM
腺病毒感染需要病毒附着在细胞上并内化。病毒纤维蛋白与特定的细胞表面受体之间的相互作用，如46-kDa柯萨奇病毒和腺病毒受体(CAR)，负责附着；病毒五肽碱基和细胞表面整合素之间的第二个相互作用促进病毒内化。受体的表达可能决定组织对腺病毒感染和腺病毒介导的基因传递是否易感。(C)1999年爱思唯尔科学公司。
Adenovirus infection requires that the virus attach to cells and be internalized. Interaction between the viral fiber protein and specific cell surface receptors, such as the 46-kDa coxsackievirus and adenovirus receptor (CAR), is responsible for attachment; a second interaction between the viral penton base and cell surface integrins facilitates virus internalization. Expression of receptors may determine whether tissues are susceptible to adenovirus infection and adenovirus-mediated gene delivery. (C) 1999 Elsevier Science Inc.