DEMOGRAPHY OF GENOTYPES - FAILURE OF THE LIMITED LIFE-SPAN PARADIGM IN DROSOPHILA-MELANOGASTER
DEMOGRAPHY OF GENOTYPES - FAILURE OF THE LIMITED LIFE-SPAN PARADIGM IN DROSOPHILA-MELANOGASTER
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DOI：
10.1126/science.1411541
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发表时间：
1992-10-16
期刊：
影响因子：
56.9
通讯作者：
VAUPEL, JW
中科院分区：
文献类型：
--
作者：
CURTSINGER, JW;FUKUI, HH;VAUPEL, JW
实验系统，是经得起遗传操作，可以用来解决有关遗传和非遗传因素的长寿的基本问题。对10种基因型的黑腹果蝇（Drosophila melanogaster）在有利于延长生存期的条件下饲养的大型队列进行分析，发现基因型之间年龄特异性死亡率曲线的斜率和位置存在差异。对单个基因型的更详细的研究表明，死亡率轨迹最适合两阶段Gompertz模型，在羽化后30天内死亡率没有年龄特异性增加。这些结果是相反的有限寿命的范例，假设明确定义的，基因型特异性的限制寿命和短暂的激烈和迅速加速的死亡率在最古老的年龄。
Experimental systems that are amenable to genetic manipulation can be used to address fundamental questions about genetic and nongenetic determinants of longevity. Analysis of large cohorts of ten genotypes of Drosophila melanogaster raised under conditions that favored extended survival has revealed variation between genotypes in both the slope and location of age-specific mortality curves. More detailed examination of a single genotype showed that the mortality trajectory was best fit by a two-stage Gompertz model, with no age-specific increase in mortality rates beyond 30 days after emergence. These results are contrary to the limited life-span paradigm, which postulates well-defined, genotype-specific limits on life-span and brief periods of intense and rapidly accelerating mortality rates at the oldest ages.