Reproductive hormonal changes and catamenial pattern in adolescent females with epilepsy
Reproductive hormonal changes and catamenial pattern in adolescent females with epilepsy
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DOI：
10.1111/j.1528-1167.2008.01622.x
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发表时间：
2008-09-01
期刊：
影响因子：
5.6
通讯作者：
Shatla, Rania H.
中科院分区：
文献类型：
--
作者：
El-Khayat, Hamed A.;Soliman, Nancy A.;Shatla, Rania H.
目的：我们旨在评估癫痫对女性患者生殖激素水平的影响，并调查月经期癫痫发作的频率。方法：纳入42名女性癫痫患者和21名健康女性（对照组）。受试者月经初潮后至少 2 年，月经周期规律。使用经前经历评分日历来评估经前综合症（PMS）的症状。对患者的月经期癫痫发作模式进行评估。在周期的三个阶段对所有受试者的 FSH、LH、雌二醇 (E) 和孕酮 (P) 水平进行评估。在临近排卵时进行盆腔腹部超声检查，以追踪成熟卵泡的大小。结果：PMS 的症状在患者和对照组、有月经倾向的患者和无月经倾向的患者中没有差异。在围经期（M）和黄体中期，患者组的 FSH 和 P 水平较低，E/P 比值较高。 31% 的患者存在经期癫痫发作模式（53.8% M C 1；46.15% 黄体期 C-3 模式不足）。与非月经型患者、C-1 型患者或对照组相比，C-3 型患者在黄体中期表现出较低的 P 水平。 C-1型患者M期P水平低于对照组。结论：女性癫痫患者生殖激素存在明显紊乱，FSH和P水平较低，E/P比值较高。总共 31% 的患者表现出经期癫痫发作模式（C-1 和 C-3 模式），与停药显着相关。
Purpose: We aimed to evaluate the effect of epilepsy on the reproductive hormones levels among female patients, and to investigate the frequency of catamenial pattern of seizures.Methods: A total of 42 female patients with epilepsy and 21 healthy females (control group) were included. Subjects were at least 2 years post-menarche with regular cycles. Symptoms of premenstrual syndrome (PMS) were assessed using calendar of premenstrual experience scoring. Patients were evaluated for catamenial pattern of seizures. Levels of FSH, LH, estradiol (E), and progesterone (P) were assessed for all subjects in the three phases of the cycles. Pelvi-abdominal ultrasound was performed near time of ovulation, to follow up size of mature follicle.Results: Symptoms of PMS were not different in patients and controls, or in patients with and those without catamenial tendency. In both perimenstrual (M) and midluteal phases, FSH and P levels were lower and E/P ratio higher in patients group. There was a catamenial pattern of seizures in 31% of patients (53.8% M C 1; 46.15% inadequate luteal phase C-3 pattern). Patients with C-3 pattern showed lower P levels in the midluteal phase compared to patients with noncatamenial pattern, to those with C-1 pattern or to controls. Patients with C-1 pattern had lower P levels than controls in the M phase.Conclusion: There was evident disruption in the reproductive hormones in female patients with epilepsy with lower FSH and P levels and higher E/P ratio. A total of 31% of patients showed catamenial pattern of seizures (C-1 and C-3 patterns) that was significantly related to P withdrawal.