Correspondence of the brain's functional architecture during activation and rest
Correspondence of the brain's functional architecture during activation and rest
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DOI：
10.1073/pnas.0905267106
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发表时间：
2009-08-04
影响因子：
11.1
通讯作者：
Beckmann, Christian F.
中科院分区：
文献类型：
--
作者：
Smith, Stephen M.;Fox, Peter T.;Beckmann, Christian F.
为功能网络提供底物的神经连接是否在任何给定时刻都在功能上有效。但是，当大脑“静止”时，尚不清楚大脑区域在多大程度上连续相互作用。在这项工作中，我们通过进行基于图像的激活网络分析数千个单独的激活来确定主要的显式激活网络。源自功能成像研究的脑图数据库，涉及近30,000名人类受试者。在静止的36个受试者中成像。即使在“休息”时，即使在“休息”时连续和动态“活动”。
Neural connections, providing the substrate for functional networks, exist whether or not they are functionally active at any given moment. However, it is not known to what extent brain regions are continuously interacting when the brain is "at rest.'' In this work, we identify the major explicit activation networks by carrying out an image-based activation network analysis of thousands of separate activation maps derived from the BrainMap database of functional imaging studies, involving nearly 30,000 human subjects. Independently, we extract the major covarying networks in the resting brain, as imaged with functional magnetic resonance imaging in 36 subjects at rest. The sets of major brain networks, and their decompositions into subnetworks, show close correspondence between the independent analyses of resting and activation brain dynamics. We conclude that the full repertoire of functional networks utilized by the brain in action is continuously and dynamically "active'' even when at "rest.''