A neural command circuit for grooming movement control
A neural command circuit for grooming movement control
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DOI：
10.7554/elife.08758
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发表时间：
2015-09-07
期刊：
影响因子：
7.7
通讯作者：
Seeds, Andrew M.
中科院分区：
文献类型：
--
作者：
Hampel, Stefanie;Franconville, Romain;Seeds, Andrew M.
动物执行许多刻板的动作，但神经系统是如何组织控制特定的运动仍然不清楚。在这里，我们使用解剖学，光遗传学，行为和生理学技术，以确定在果蝇的电路，可以引起定型的腿部运动，梳理触角。机械感觉弦音神经元检测触角的位移，并激发三种不同类型的功能连接的中间神经元，其中包括两类大脑中间神经元和不同的平行下行神经元。这种多层电路的组织方式使得每层内的神经元都足以特异性地引起触角梳理。然而，我们发现在不同的层中的神经元引起的触角梳理的持续时间的差异，这表明电路的组织都命令触角梳理和控制其持续时间。由于类似的功能在其他动物刺激诱导的运动的基础上，我们推断的可能性，一个共同的电路组织的运动控制，可以在果蝇解剖。
Animals perform many stereotyped movements, but how nervous systems are organized for controlling specific movements remains unclear. Here we use anatomical, optogenetic, behavioral, and physiological techniques to identify a circuit in Drosophila melanogaster that can elicit stereotyped leg movements that groom the antennae. Mechanosensory chordotonal neurons detect displacements of the antennae and excite three different classes of functionally connected interneurons, which include two classes of brain interneurons and different parallel descending neurons. This multilayered circuit is organized such that neurons within each layer are sufficient to specifically elicit antennal grooming. However, we find differences in the durations of antennal grooming elicited by neurons in the different layers, suggesting that the circuit is organized to both command antennal grooming and control its duration. As similar features underlie stimulus-induced movements in other animals, we infer the possibility of a common circuit organization for movement control that can be dissected in Drosophila.