Pet exposure and risk of atopic dermatitis at the pediatric age: A meta-analysis of birth cohort studies
Pet exposure and risk of atopic dermatitis at the pediatric age: A meta-analysis of birth cohort studies
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DOI：
10.1016/j.jaci.2013.04.009
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发表时间：
2013-09-01
影响因子：
14.2
通讯作者：
Chatenoud, Liliane
中科院分区：
文献类型：
--
作者：
Pelucchi, Claudio;Galeone, Carlotta;Chatenoud, Liliane
背景：宠物暴露与儿童特应性皮炎（AD）风险的研究结果不一致。目的：为了总结接触不同宠物对AD的影响，我们对这一问题的流行病学研究进行了荟萃分析。方法：于2012年8月在Medline和Embase进行系统文献检索。我们纳入了考虑在怀孕、婴儿期和/或儿童期接触狗、猫、其他宠物或宠物的分析研究，并在婴儿期或儿童期进行AD评估。我们使用固定效应和随机效应模型计算了总相对风险和95% ci。我们计算了选定子组的汇总估计。结果：meta分析使用了来自21项出生队列研究的26篇出版物。与未接触相比，接触狗的AD总相对危险度为0.72 （95% CI, 0.61-0.85; I-2 = 46%；基于15项研究的结果），接触猫的AD总相对危险度为0.94 （95% CI, 0.76-1.16; I-2 = 54%；基于13项研究的结果），接触宠物的AD总相对危险度为0.75 （95% CI, 0.67-0.85; I-2 = 54%；基于11项研究的结果）。除了地理区域外，在检查的亚组中没有出现异质性。结论：这项荟萃分析报告了接触狗和宠物对婴儿或儿童患阿尔茨海默病的风险有有利影响，而与猫接触没有关联。
Background: Findings on pet exposure and the risk of atopic dermatitis (AD) in children are inconsistent.Objective: With the aim to summarize the results of exposure to different pets on AD, we undertook a meta-analysis of epidemiologic studies on this issue.Methods: In August 2012, we conducted a systematic literature search in Medline and Embase. We included analytic studies considering exposure to dogs, cats, other pets, or pets overall during pregnancy, infancy, and/or childhood, with AD assessment performed during infancy or childhood. We calculated summary relative risks and 95% CIs using both fixed-and random-effects models. We computed summary estimates across selected subgroups.Results: Twenty-six publications from 21 birth cohort studies were used in the meta-analyses. The pooled relative risks of AD for exposure versus no exposure were 0.72 (95% CI, 0.61-0.85; I-2 = 46%; results based on 15 studies) for exposure to dogs, 0.94 (95% CI, 0.76-1.16; I-2 = 54%; results based on 13 studies) for exposure to cats, and 0.75 (95% CI, 0.67-0.85; I-2 = 54%; results based on 11 studies) for exposure to pets overall. No heterogeneity emerged across the subgroups examined, except for geographic area.Conclusion: This meta-analysis reported a favorable effect of exposure to dogs and pets on the risk of AD in infants or children, whereas no association emerged with exposure to cats.