Associations Between Genomic Variants in lncRNA-TRPM2-AS and lncRNA-HNF1A-AS1 Genes and Risk of Multiple Sclerosis
Associations Between Genomic Variants in lncRNA-TRPM2-AS and lncRNA-HNF1A-AS1 Genes and Risk of Multiple Sclerosis
复制标题
DOI：
10.1007/s12031-020-01504-z
复制
发表时间：
2020-02-26
影响因子：
3.1
通讯作者：
Karimipoor, Morteza
中科院分区：
文献类型：
--
作者：
Bahrami, Tayyeb;Taheri, Mohammad;Karimipoor, Morteza
多发性硬化症（MS）是一种复杂的遗传性状，以中枢神经系统（CNS）脱髓鞘、炎症和进行性神经功能障碍为特征。有证据表明，自噬和应激机制与ms密切相关。先前的研究表明，LncRNAs TRPM2-AS和HNF1A-AS1分别参与氧化应激和自噬。在目前的研究中，我们调查了300名伊朗患者和300名健康对照者的TRPM2-AS和HNF1A-AS1单核苷酸多态性（snp）与MS风险的关系。我们的研究结果显示，与健康受试者相比，MS患者中rs933151的T等位基因代表性不足(OR （95% CI) = 0.696 (0.532-0.911), P = 0.005）。在共显性和显性模型中，该SNP与较低的MS风险相关(OR (95% CI) = 0.68 (0.48-0.96)， P值= 0.032；OR （95% CI) = 0.65 (0.47-0.91)， P值分别= 0.012）。rs7953249在任何遗传模型中均与MS易感性无关（共显性、显性、隐性和过显性模型的P值分别为0.73、0.46、0.61和0.71）。目前的研究强调了TRPM2-AS基因（SNP rs933151）与MS易感性的新关联。
Multiple sclerosis (MS) is a complex genetic trait characterized by demyelination of central nervous system (CNS), inflammation, and progressive neurological dysfunction. There is evidenced that autophagy and stress mechanisms are tightly linked with MS. Previous studies have demonstrated that LncRNAs TRPM2-AS and HNF1A-AS1 are involved in oxidative stress and autophagy, respectively. In the current study, we investigated the association of TRPM2-AS and HNF1A-AS1 single nucleotide polymorphisms (SNPs) with MS risk in 300 Iranian patients and 300 healthy controls. Our results have shown that T allele of the rs933151 was statistically significant underrepresented in MS patients compared with healthy subjects (OR (95% CI) = 0.696 (0.532-0.911), P = 0.005). This SNP was associated with lower MS risk in codominant and dominant models (OR (95% CI) = 0.68 (0.48-0.96), P value = 0.032; OR (95% CI) = 0.65 (0.47-0.91), P value = 0.012, respectively). The rs7953249 was not associated with MS susceptibility in any inheritance models (P values of 0.73, 0.46, 0.61, and 0.71 for codominant, dominant, recessive, and overdominant models, respectively). Present study highlighted a novel association at the TRPM2-AS gene (SNP rs933151) with MS susceptibility.