Behavioral Symptoms after Breast Cancer Treatment: A Biobehavioral Approach.
Behavioral Symptoms after Breast Cancer Treatment: A Biobehavioral Approach.
复制标题
乳腺癌治疗后的行为症状：一种生物行为方法。
DOI：
10.3390/jpm5030280
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发表时间：
2015-08-03
影响因子：
--
通讯作者：
Karuga M
中科院分区：
文献类型：
--
作者：
Fagundes C;LeRoy A;Karuga M
乳腺癌的诊断和治疗在情感和身体上都具有挑战性。乳腺癌是美国最常见的癌症，也是导致女性死亡的第二大原因。因此，有乳腺癌病史的女性是女性癌症幸存者中最大的群体。心理应激极大地增加了不利的自主神经、内分泌和免疫排放，包括促炎细胞因子的产生。重要的是，炎症是疼痛、抑郁、疲劳和睡眠障碍等症状群的关键生物学机制；也有充分的证据表明，炎症有助于乳腺癌的复发。应激可直接影响心理和生理风险过程。在这篇综述中，我们采用生物行为学的方法来了解乳腺癌幸存者躯体症状的预测因素和机制。
Being diagnosed and treated for breast cancer is emotionally and physically challenging. Breast cancer is the most commonly diagnosed cancer and the second leading cause of death for women in the United States. Accordingly, women with a breast cancer history are the largest group of female cancer survivors. Psychological stress substantially augments adverse autonomic, endocrine, and immune discharge, including enhanced production of proinflammatory cytokines. Importantly, inflammation is a key biological mechanism underlying the symptom cluster of pain, depression, fatigue, and sleep disturbances; there is also good evidence that inflammation contributes to breast cancer recurrence. Stress may exert direct effects on psychological and physiological risk processes. In this review, we take a biobehavioral approach to understanding predictors and mechanisms underlying somatic symptoms in breast cancer survivors.