Water retention in the acute phase of Kawasaki disease: relationship between oedema and the development of coronary arterial lesions
Water retention in the acute phase of Kawasaki disease: relationship between oedema and the development of coronary arterial lesions
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DOI：
10.1007/s00431-003-1326-4
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发表时间：
2003-12-01
影响因子：
3.6
通讯作者：
Yoshikawa, N
中科院分区：
文献类型：
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作者：
Suzuki, H;Takeuchi, T;Yoshikawa, N
尽管接受静脉注射免疫球蛋白治疗，仍有一定比例的川崎病（KD）患者出现冠状动脉病变（CAL）。为了寻找新的联合治疗方法来降低CAL的发生率，我们将重点放在水肿上，这可能是KD血管通透性增加的重要标志。共有127例KD患者被纳入回顾性研究。连续每周的变化，血清钠和白蛋白水平从第1至第4周的疾病进行了检查。此外，还评估了从入院至患病第14天的体重最大增加率。仅在发病第2周，CAL患者的血清钠水平（mEq/l）显著低于无CAL患者（平均值± SD，135.5 ± 4.5 vs 138.0 ± 2.4，P
Despite intravenous immunoglobulin therapy, a certain percentage of patients with Kawasaki disease (KD) still develop coronary arterial lesions (CAL). In an effort to find new combined therapies to reduce the incidence of CAL, we focused on the oedema which can be an important sign of the increased vascular permeability in KD. A total of 127 patients with KD were included in the retrospective study. Serial weekly changes in serum sodium and albumin levels from the 1st to the 4th week of illness were examined. In addition, the maximum rate of increase in body weight from admission to the 14th day of illness was evaluated. Serum sodium levels (mEq/l) in only the 2nd week of illness were significantly lower in patients with CAL than in those without CAL (mean +/- SD, 135.5+/-4.5 versus 138.0+/-2.4, P