Compartmentalized cAMP signaling in cardiac ventricular myocytes.
Compartmentalized cAMP signaling in cardiac ventricular myocytes.
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DOI：
10.1016/j.cellsig.2021.110172
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发表时间：
2022-01
影响因子：
4.8
通讯作者：
Harvey RD
中科院分区：
文献类型：
--
作者：
Agarwal SR;Sherpa RT;Moshal KS;Harvey RD
通过产生共同的第二信使环磷酸腺苷（cAMP）起作用的不同受体的激活可以在心肌细胞中引起不同的功能反应。选择性地将cAMP活性隔离到离散的细胞内微结构域被认为是产生受体特异性应答所必需的。然而，控制区室化cAMP信号传导的这一方面的过程并不完全清楚。多年来，技术创新在促进我们对cAMP区室化机制的理解方面提供了关键突破。确定的一些因素包括通过受体的差异分布局部产生cAMP，通过磷酸二酯酶的靶向分布局部分解该第二信使，以及通过蛋白激酶A（PKA）依赖性缓冲或物理限制性屏障限制cAMP的扩散。这篇综述的目的是提供一个讨论我们目前的知识，并强调一些差距，仍然存在于该领域的cAMP compartmentation在心肌细胞。
Activation of different receptors that act by generating the common second messenger cyclic adenosine monophosphate (cAMP) can elicit distinct functional responses in cardiac myocytes. Selectively sequestering cAMP activity to discrete intracellular microdomains is considered essential for generating receptor-specific responses. The processes that control this aspect of compartmentalized cAMP signaling, however, are not completely clear. Over the years, technological innovations have provided critical breakthroughs in advancing our understanding of the mechanisms underlying cAMP compartmentation. Some of the factors identified include localized production of cAMP by differential distribution of receptors, localized breakdown of this second messenger by targeted distribution of phosphodiesterase enzymes, and limited diffusion of cAMP by protein kinase A (PKA)-dependent buffering or physically restricted barriers. The aim of this review is to provide a discussion of our current knowledge and highlight some of the gaps that still exist in the field of cAMP compartmentation in cardiac myocytes.
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影响因子：
20.1
作者：
Beca, Sanja;Ahmad, Faiyaz;Backx, Peter H.
通讯作者：
Backx, Peter H.
心脏肥大中营地磷酸二酯酶的表达和活性下降及其对β-肾上腺素能cAMP信号的影响。
影响因子：
20.1
作者：
Abi-Gerges A;Richter W;Lefebvre F;Mateo P;Varin A;Heymes C;Samuel JL;Lugnier C;Conti M;Fischmeister R;Vandecasteele G
通讯作者：
Vandecasteele G
DOI：
10.1073/pnas.262787199
发表时间：
2003-02-04
影响因子：
11.1
作者：
Baillie, GS;Sood, A;Houslay, MD
通讯作者：
Houslay, MD
影响因子：
64.5
作者：
Crackower, MA;Oudit, GY;Penninger, JM
通讯作者：
Penninger, JM
影响因子：
5.5
作者：
Belevych, AE;Sims, C;Harvey, RD
通讯作者：
Harvey, RD