Osteoarthritis of the knee
Osteoarthritis of the knee
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DOI：
10.1056/nejmcp051726
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发表时间：
2006-02-23
影响因子：
158.5
通讯作者：
Felson, DT
中科院分区：
文献类型：
--
作者：
Felson, DT
一位66岁的超重妇女报告说，在过去的几个月里，她的双侧膝关节疼痛逐渐发作，这越来越限制了她的活动。上周，当她走下楼梯时，膝盖一软，差点摔倒。她不记得自己的膝盖受伤了，她没有晨僵，其他关节也没有疼痛。她曾尝试每天服用8片强效（每片500毫克）对乙酰氨基酚片，但没有成功，从未出现溃疡或胃出血。患者应如何评估和治疗？
A 66-year-old woman who is overweight reports bilateral knee pain of gradual onset during the past several months that increasingly has limited her activities. Last week, when walking down the stairs, she nearly fell when her knee gave way. She does not recall having injured her knee, and she has no morning stiffness and no pain in other joints. She has tried taking up to eight extra-strength ( 500 mg each) acetaminophen tablets daily without success and has never had ulcers or stomach bleeding. How should the patient be evaluated and treated?