EFFECTS OF SMOKING ON FETOPLACENTAL-MATERNAL SYSTEM DURING PREGNANCY
EFFECTS OF SMOKING ON FETOPLACENTAL-MATERNAL SYSTEM DURING PREGNANCY
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DOI：
10.1016/0002-9378(84)90156-x
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发表时间：
1984-01-01
影响因子：
9.8
通讯作者：
OHTSU, T
中科院分区：
文献类型：
--
作者：
MOCHIZUKI, M;MARUO, T;OHTSU, T
通过对胎儿胎盘功能和孕妇营养状况的评估，探讨吸烟孕妇胎儿生长迟缓的机制。还进行了硫酸脱氢表雄酮（DHA-S）负荷试验和尼古丁主要代谢产物可替宁的测定。在重度吸烟者中，尿雌三醇和血清人胎盘催乳素（hPL）水平低于非吸烟者。吸烟者和不吸烟者之间的母亲营养没有差异。重度吸烟者表现出较低的DHA-S转化为雌二醇比不吸烟者。重度吸烟者母血和脐血中可替宁离子水平显著高于非吸烟者。显微镜检查显示，胎盘绒毛萎缩和血管减少的变化，从母亲谁吸烟。显然，重度吸烟者胎儿生长迟缓是由于尼古丁的血管收缩作用导致子宫胎盘循环受损。
Fetoplacental function and maternal nutritional condition were assessed to clarify the mechanism of retarded fetal growth in pregnant women who smoked. Dehydroepiandrosterone sulfate (DHA-S) loading tests and measurements of cotinine, which is a major metabolite of nicotine, were also made. In heavy smokers, urinary estriol and serum levels of human placental lactogen (hPL) were lower than those in nonsmokers. There was no difference in maternal nutrition between smokers and nonsmokers. Heavy smokers demonstrated a lower conversion of DHA-S to estradiol than did nonsmokers. Levels of cotinine ion maternal blood and umbilical cord blood of heavy smokers were remarkably higher than those in nonsmokers. Microscopic examinations showed atrophic and hypovascular changes in placental villi from mothers who smoked. Evidently, retarded fetal growth in heavy smokers is due to impairment of uteroplacental circulation as a result of the vasoconstricting effect of nicotine.