Simulating optical memory effects and the scanning of foci using wavefront shaping in tissue-like scattering media
Simulating optical memory effects and the scanning of foci using wavefront shaping in tissue-like scattering media
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DOI：
10.1117/12.2670438
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发表时间：
2023-08
期刊：
影响因子：
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通讯作者：
Jake A. J. Bewick;P. Munro;S. Arridge;J. Guggenheim
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文献类型：
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作者：
Jake A. J. Bewick;P. Munro;S. Arridge;J. Guggenheim
波前整形可以使光聚焦在散射介质的深处，增加光学显微镜和光学相干断层扫描等成像技术的深度和分辨率。然而，由于微尺度运动和热变化导致的快速去相关时间等因素使得难以聚焦活组织。一种减轻要求的方法可以是利用记忆效应提供的先验信息。例如，这可以允许部分或全部扫描焦点。为了研究这一点和相关的想法，一个计算模型被开发来模拟由WFS在散射介质中形成的焦点的产生和相关性。角记忆范围的预测与实验观察结果一致。此外，在聚焦于不同位置所需的光学相位图之间观察到的相关性表明，基于相关性的先验可能会加速聚焦。这项工作可以为更快的光学聚焦铺平道路，从而在活组织中进行更深入的成像。
Wavefront shaping could enable focusing light deep inside scattering media, increasing the depth and resolution of imaging techniques like optical microscopy and optical coherence tomography. However, factors like rapid decorrelation times due to microscale motion and thermal variation make focusing on living tissue difficult. A way to ease the requirements could be exploiting prior information provided by memory effects. For example, this might allow partially or wholly scanning a focus. To study this and related ideas, a computational model was developed to simulate the generation and correlations of foci formed by WFS in scattering media. Predictions of the angular memory range were consistent with experimental observations. Furthermore, correlations observed between optical phase maps required to focus on different positions suggested correlation-based priors might enable accelerated focusing. This work could pave the way to faster optical focusing and thus deeper imaging in living tissue.