Modeling tumor regrowth and immunotherapy
Modeling tumor regrowth and immunotherapy
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DOI：
10.1016/s0895-7177(00)00314-9
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发表时间：
2001-06-01
影响因子：
--
通讯作者：
Knott, GD
中科院分区：
文献类型：
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作者：
Kuznetsov, VA;Knott, GD
描述肿瘤生长机制的确定性模型。抑制和再生长，并拟合小鼠B细胞淋巴瘤的动力学数据。研究表明，杀伤细胞抑制效果的适度变化，或肿瘤细胞的变异非免疫原性克隆的存在，都可以解释初始抑制后肿瘤的再生长。建立癌症休眠后的辅助免疫疗法被建模为杀伤细胞进入肿瘤的方式的刺激增加或这些细胞在肿瘤中增殖速率的局部增加。我们模拟了由在肿瘤附近脉冲注射免疫淋巴细胞组成的免疫疗法。我们的数值实验表明，这种免疫疗法不会完全摧毁肿瘤，尽管此后肿瘤可能会持续处于休眠癌症状态，或明显延迟其再生长。(C)2001爱思唯尔科技有限公司版权所有。
Deterministic models describing mechanisms underlying tumor growth. suppression and regrowth are proposed and fit to kinetic data on B cell lymphoma in mice. It is demonstrated that either a modest change in the effectiveness of killer cell suppression, or the existence of a variant nonimmunogenic clone of the tumor cells, call explain the regrowth of a tumor after initial suppression. Adjuvant immunotherapy after establishing the cancer dormancy is modeled as a stimulated increase of the how of killer cells into the tumor or a local increase of the rate of proliferation of these cells ill a, tumor. We modeled the immunotherapy consisting of impulse injections of immune lymphocytes in the vicinity of the tumor. Our numerical experiments show that this immunotherapy does not completely destroy the tumor, although thereafter the tumor may persist in a dormant cancer state ol have its regrowth markedly delayed. (C) 2001 Elsevier Science Ltd. All rights reserved.