SCINTIGRAPHIC LOCALIZATION OF PHEOCHROMOCYTOMA
SCINTIGRAPHIC LOCALIZATION OF PHEOCHROMOCYTOMA
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DOI：
10.1056/nejm198107023050103
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发表时间：
1981-01-01
影响因子：
158.5
通讯作者：
THOMPSON, NW
中科院分区：
文献类型：
--
作者：
SISSON, JC;FRAGER, MS;THOMPSON, NW
本文报道了一种新的放射性药物[131 I]间碘苄胍（[131 I]MIBG）对8例嗜铬细胞瘤的显像。注射后1天或更长时间，显示不同放射性浓度的唯一正常器官是膀胱。[131 I]MIBG可能集中在肾上腺素能囊泡中;在囊泡众多的组织中，如嗜铬细胞瘤，放射性核素可保留数天。肾上腺嗜铬细胞瘤的X线表现为肾上腺内、肾上腺外、良性、恶性、重量0.2 ~ 65 g、激素分泌方式不同。4例CT未发现肿瘤。在1例患者中，再次手术仅是因为肾上腺造影片定位了肾上腺外肿瘤，从而指导了外科医生的探查。该方法提供了安全和可靠的定位嗜铬细胞瘤在他们的许多伪装的希望。
A new radiopharmaceutical agent, [131I]meta-iodobenzylguanidine ([131I]MIBG), was used to produce scintigraphic images of pheochromocytomas in 8 patients. One day or more after injection, the only normal organ that displayed distinct concentrations of radioactivity was the urinary bladder. The [131I]MIBG was probably concentrated in adrenergic vesicles; in tissues where vesicles are numerous, such as pheochromocytomas, the radionuclide was retained for days. The spectrum of pheochromocytomas shown on the scintigrams was broad: intra-adrenal and extra-adrenal in location, benign and malignant in character, 0.2-65 g in wt, and with different hormone patterns in secretion. Tumors in 4 patients were not detected by computed tomography. In 1 patient, reoperation was undertaken only because the scintigram located the extra-adrenal tumors and thereby directed the surgeon''s exploration. The method offers hope of safe and reliable localization of pheochromocytomas in their many guises.