NEUROGENESIS PERSISTS IN THE SUBEPENDYMAL LAYER OF THE ADULT-MOUSE BRAIN
NEUROGENESIS PERSISTS IN THE SUBEPENDYMAL LAYER OF THE ADULT-MOUSE BRAIN
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DOI：
10.1016/0304-3940(93)90748-a
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发表时间：
1993-01-12
影响因子：
2.5
通讯作者：
MARUNIAK, JA
中科院分区：
文献类型：
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作者：
COROTTO, FS;HENEGAR, JA;MARUNIAK, JA
已知嗅球颗粒细胞的神经发生在成年大鼠中持续存在，在某些品系中，嗅球在整个生命中生长。在小鼠中，灯泡生长在成年早期停止，在这里我们问颗粒细胞神经发生是否在灯泡停止生长后持续。通过注射成年小鼠溴脱氧尿苷（BrdU），并允许短期和长期的生存时间，我们发现，新的细胞形成室管膜下层，他们随后迁移到嗅球，在那里他们获得颗粒细胞的核形态和表达神经元特异性标记。使用[H-3]胸苷，我们发现，大多数这些成人产生的颗粒神经元持续在球内至少16周。这表明在嗅球停止生长的成年动物中神经发生和神经元迁移的持续性。
Neurogenesis of olfactory bulb granule cells is known to persist in adult rats where, in some strains, the bulbs grow throughout life. In mice, bulb growth ceases early in adulthood and here we ask if granule cell neurogenesis persists after the bulbs have stopped growing. By injecting adult mice with bromodeoxyuridine (BrdU) and allowing short and long survival times, we found that new cells form in the subependymal layer and that they migrate subsequently into the olfactory bulbs where they acquire the nuclear morphology of granule cells and express neuron-specific markers. Using [H-3]thymidine, we found that most of these adult-generated granule neurons persist within the bulbs for at least 16 weeks. This shows the persistence of neurogenesis and neuronal migration in adult animals in which the olfactory bulbs have stopped growing.