Effect of calcium and vitamin D supplementation on bone, density in men and women 65 years of age or older
Effect of calcium and vitamin D supplementation on bone, density in men and women 65 years of age or older
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DOI：
10.1056/nejm199709043371003
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发表时间：
1997-09-04
影响因子：
158.5
通讯作者：
Dallal, GE
中科院分区：
文献类型：
--
作者：
DawsonHughes, B;Harris, SS;Dallal, GE
背景钙和维生素D的饮食摄入不足可能会导致骨质疏松症的高患病率老年人among older persons.Methods我们研究了三年的膳食补充钙和维生素D对骨密度，骨代谢的生化指标和非椎骨骨折的发病率在176名男性和213名女性65岁或以上谁住在家里。他们每天接受500毫克钙加700 IU维生素D-3（胆钙化醇）或安慰剂。采用双能X线吸收法测量骨密度，每6个月分析一次血液和尿液，通过访谈确定非脊椎骨折病例，并使用医院记录进行验证。结果钙-维生素D组和安慰剂组骨密度的平均（+/-SD）变化如下：股骨颈分别为+0.50+/-4.80和-0.70+/-5.03%（P=0.02）;脊柱分别为+2.12+/-4.06和+1.22+/-4.25%（P=0.04）;全身分别为+0.06+/-1.83和-1.09+/-1.71%（P< 0.001）。一年后，钙-维生素D组和安慰剂组之间的差异在所有骨骼部位都是显著的，但仅在第二年和第三年的全身骨矿物质密度上有显著性差异。在37名非椎骨骨折的受试者中，安慰剂组有26名，钙-维生素D组有11名（P=0.02）。结论在生活在社区的65岁或以上的男性和女性中，膳食补充钙和维生素D适度减少了股骨颈，脊柱，在三年的研究期内，(C)1997年，马萨诸塞州医学会。
Background Inadequate dietary intake of calcium and vitamin D may contribute to the high prevalence of osteoporosis among older persons.Methods We studied the effects of three years of dietary supplementation with calcium and vitamin D on bone mineral density, biochemical measures of bone metabolism and the incidence of nonvertebral fractures in 176 men and 213 women 65 years of age or older who were living at home. They received either 500 mg of calcium plus 700 IU of vitamin D-3 (cholecalciferol) per day or placebo. Bone mineral density was measured by dual-energy x-ray absorptiometry, blood and urine were analyzed every six months, and cases of nonvertebral fracture were ascertained by means of interviews and verified with use of hospital records.Results The mean (+/-SD) changes in bone mineral density in the calcium-vitamin D and placebo groups were as follows: femoral neck, +0.50+/-4.80 and -0.70+/-5.03 percent, respectively (P=0.02); spine, +2.12+/-4.06 and +1.22+/-4.25 percent (P=0.04); and total body, +0.06+/-1.83 and -1.09+/-1.71 percent (P< 0.001). The difference between the calcium-vitamin D and placebo groups was significant at all skeletal sites after, one year, but it was significant only for total-body bone mineral density in the second and third years. Of 37 subjects who had nonvertebral fractures, 26 were in the placebo group and 11 were in the calcium-vitamin D group (P=0.02).Conclusions In men and women 65 years of age or older who are living in the community, dietary supplementation with calcium and vitamin D moderately reduced bone loss measured in the femoral neck, spine, and total body over the three-year study period and reduced the incidence of nonvertebral fractures. (C) 1997, Massachusetts Medical Society.