Models of inflammation: carrageenan air pouch.
Models of inflammation: carrageenan air pouch.
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DOI：
10.1002/0471141755.ph0506s56
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发表时间：
2012-03
影响因子：
--
通讯作者：
Fehrenbacher JC
中科院分区：
文献类型：
--
作者：
Duarte DB;Vasko MR;Fehrenbacher JC
皮下气囊是一种体内模型，可用于研究急性和慢性炎症的成分、炎症反应的消退、氧化应激反应以及治疗炎症的潜在治疗靶点。将刺激物注射到大鼠或小鼠的气囊中会诱发炎症反应，该炎症反应可以通过产生的渗出液量、细胞浸润和炎症介质的释放来量化。本单元提出的模型已广泛用于识别潜在的抗炎药物。
The subcutaneous air pouch is an in vivo model that can be used to study the components of acute and chronic inflammation, the resolution of the inflammatory response, the oxidative stress response, and potential therapeutic targets for treating inflammation. Injection of irritants into an air pouch in rats or mice induces an inflammatory response that can be quantified by the volume of exudate produced, the infiltration of cells, and the release of inflammatory mediators. The model presented in this unit has been extensively used to identify potential anti-inflammatory drugs.