Black hollow silicon oxide nanoparticles as highly efficient photothermal agents in the second near-infrared window for in vivo cancer therapy.
Black hollow silicon oxide nanoparticles as highly efficient photothermal agents in the second near-infrared window for in vivo cancer therapy.
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DOI：
10.1016/j.biomaterials.2017.07.037
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发表时间：
2017-10
期刊：
影响因子：
14
通讯作者：
Xujiang Yu;Kai Yang;Xiaoyuan Chen;Wanwan Li
中科院分区：
文献类型：
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作者：
Xujiang Yu;Kai Yang;Xiaoyuan Chen;Wanwan Li
具有局部表面等离子体共振（LSPR）的半导体纳米粒子由于其在纳米医学，特别是在癌症光热治疗领域的潜在应用而受到越来越多的关注。在这项研究中，我们利用镁热还原工艺合成了非化学计量的空心氧化硅纳米颗粒（H-SiOxNPs）。黑色NPs在第二个近红外（NIR-II）窗口产生了理想的LSPR，在1064 nm处光热转换效率高达48.6%。这种效率是贵金属和半导体基NPs作为NIR-II PTT光热剂中报道的最高的。此外，H-SiOxNPs表现出优异的体内光声（PA）成像特性，因此可以用于1064 nm激光的高效体内肿瘤治疗，即使是0.6 W cm−2的激光。这些发现首次证明了LSPR存在于非化学计量硅基纳米颗粒中，具有低毒性的体内应用降解途径，并为理解新型半导体纳米颗粒在纳米医学中的作用提供了新的见解。
Semiconductor nanoparticles with localized surface plasmon resonance (LSPR) have gained increasing interest due to their potential for use in nanomedicine, particularly in the area of cancer photothermal therapy. In this study, we have synthesized non-stoichiometric hollow silicon oxide nanoparticles (H-SiOxNPs) using a magnesiothermic reduction process. The black NPs generated a desired LSPR in the second near-infrared (NIR-II) window, as was demonstrated by a photothermal conversion efficiency of up to 48.6% at 1064 nm. Such an efficiency is the highest reported among the noble metal and semiconductor-based NPs as NIR-II PTT photothermal agents. In addition, H-SiOxNPs exhibited excellentin vivophotoacoustic (PA) imaging properties, and thus can be used for highly efficientin vivocancer treatmentviairradiation with a 1064 nm laser, even at 0.6 W cm−2. The findings described are the first to demonstrate the existence of LSPR in non-stoichiometric silicon-based nanoparticles with a low-toxicity degradation pathway forin vivoapplication, and provide new insights towards understanding the role of new semiconductor nanoparticles in nanomedicine.