Animal models of obesity and metabolic syndrome: Potential tools for Alzheimer's disease research
Animal models of obesity and metabolic syndrome: Potential tools for Alzheimer's disease research
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DOI：
10.2174/156720507780362209
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发表时间：
2007-04-01
影响因子：
2.1
通讯作者：
Abraham, Kristin M.
中科院分区：
文献类型：
--
作者：
Abraham, Kristin M.
新出现的证据表明，代谢综合征的组分无论是孤立的还是聚集的，都可能影响神经退行性过程的发作或严重程度，包括导致阿尔茨海默病（AD）的那些生理变化。最初设计用于询问代谢综合征的几种动物模型是容易获得的。这些模型现在可用于支持可能提供代谢综合征和神经变性之间新的机制联系的研究。此外，目前通过NIDDK支持的一系列项目的努力产生和表型的动物品系可能会在不久的将来为推进阿尔茨海默病研究提供新的和更好的工具。
Emerging evidence suggests that components of the metabolic syndrome either in isolation or in aggregate may impact the onset or severity of neurodegenerative processes, including those physiologic changes that lead to Alzheimer's Disease (AD). Several animal models that were originally designed to interrogate the metabolic syndrome are readily available. These models can now be used to support studies that may provide new mechanistic links between the metabolic syndrome and neurodegeneration. In addition, animal strains currently being generated and phenotyped through the efforts of an array of NIDDK-supported projects are likely to provide novel and better tools to advance Alzheimer's disease research in the near future.