Gastric Myoelectrical Differences between Parkinson's Disease and Multiple System Atrophy
Gastric Myoelectrical Differences between Parkinson's Disease and Multiple System Atrophy
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DOI：
10.1002/mds.22265
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发表时间：
2009-08-15
影响因子：
8.6
通讯作者：
Hattori, Takamichi
中科院分区：
文献类型：
--
作者：
Sakakibara, Yumi;Asahina, Masato;Hattori, Takamichi
对17例帕金森病(PD)患者、17例多系统萎缩症(MSA)患者和8例健康对照组进行24小时胃电(EGG)检测，以阐明两种疾病胃电表现的差异。选择8个胃电节段(餐前3个，餐后3个，睡眠2个节段)进行频谱分析，得到主频(DF)、不稳定系数(ICDF)和低频段(LFR%)。正常(NFR%)和高(HFR%)范围功率占总功率的百分比。PD组表现为不规则慢波、高HFR%、高ICDF，而MSA组表现为规则慢波、低ICDF。尽管对照组的DF和NFR%在餐后有所增加，但与对照组相比，两组患者餐后DF和NFR%的增加没有那么显著。PD患者出现胃电节律紊乱，提示胃起搏功能紊乱。MSA患者表现为规则的慢波，慢波节律变异性低(低ICDF)，可能与胃自主神经功能受累有关。(C)2009年流动无序协会
The electrogastrogram (EGG) was recorded for 24 hours in 17 Parkinson's disease (PD) patients, 17 Multiple system atrophy (MSA) patients, and 8 healthy control subjects to elucidate the differences in the EGG findings between the two diseases. Eight EGG segments (3 preprandial, 3 postprandial, and 2 sleep segments) were selected front the total recording for spectral analysis, from which we obtained the dominant frequency (DF), instability coefficient of DF (ICDF), and low (LFR%). normal (NFR%), and high (HFR%) range power percentages of the total power. PD patients showed irregular slow waves, high HFR%, and high ICDF, whereas MSA patients showed regular Slow waves and low ICDF. Although DF and NFR% increased after meal in controls, postprandial increases in DF and NFR% were less significant in both patient groups compared to the controls. The PD patients presented gastric dysrhythmias indicating gastric pacemaker disturbances. The MSA patients showed regular slow waves with low variability of the slow wave rhythm (low ICDF), which might have resulted from the involvement of gastric autonomic nerve function. (C) 2009 Movement Disorder Society