Determination of Fibrinogen and Thrombin Time (TT)
Determination of Fibrinogen and Thrombin Time (TT)
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DOI：
10.1007/978-1-4939-7196-1_8
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Undas, Anetta
中科院分区：
文献类型：
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作者：
Undas, Anetta
最常用的方法是用克劳斯法测定血浆中的纤维蛋白原，该方法是根据血浆稀释液的凝血酶凝血时间与血浆标准的比较得出的。凝血酶时间(TT)是反映加入凝血酶试剂后纤维蛋白原转化为纤维蛋白的凝血指标。通过测定凝固性纤维蛋白原和凝血酶原时间，可以检测可能导致血栓或出血事件的纤维蛋白原先天(先天)和后天的定性和定量障碍。
Fibrinogen is measured in plasma most commonly using the Clauss method, based on the comparison of thrombin clotting times of dilutions of plasma against a plasma standard. Thrombin time (TT) is a coagulation assay, which reflects the conversion of fibrinogen to fibrin after addition of thrombin reagent. Measurement of clottable fibrinogen and TT allows detecting inborn (congenital) and acquired qualitative and quantitative disorders of fibrinogen that can lead to thrombotic or bleeding events.