Mechanical Oscillation of Dynamic Microtubule Rings
Mechanical Oscillation of Dynamic Microtubule Rings
复制标题
动态微管环的机械振荡
DOI：
10.1039/c6ra16613j
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发表时间：
2016
期刊：
影响因子：
3.9
通讯作者：
*Akira Kakugo
中科院分区：
文献类型：
--
作者：
Masaki Ito;Arif Md. Rashedul Kabir;Md. Sirajul Islam;Daisuke Inoue;Shoki Wada;Kazuki Sada;Akihiko Konagaya;*Akira Kakugo
机械振荡是生命系统中普遍存在的现象，它产生于各种有序的自组装结构，在许多生物过程中发挥着重要作用。虽然已经付出了相当大的努力来证明通过体外自组装产生的有组织结构的机械振荡，但很少有文献记载。在这里，我们报告的机械振荡的环形结构，由多个微管（MT）丝，通过能量耗散自组装MT丝在空气缓冲界面。MT环通过大小和形状的周期性变化表现出自主振荡。我们提出MT环的振荡是由于马达蛋白系统驱动力引起的累积应力引起的机械反馈。这项工作可能为我们目前对机械反馈驱动的有组织结构振荡及其对生命系统动力学过程的影响的理解提供新的见解。
Mechanical oscillation is a ubiquitous phenomenon observed in living systems, which emerges from a wide range of well-organized self-assembled structures, and plays important roles in many biological processes. Although considerable efforts have been devoted to demonstrate the mechanical oscillation of organized structures produced through self-assembly in vitro, it has rarely been documented. Here we report the mechanical oscillation of ring-shaped structures, composed of multiple microtubule (MT) filaments, obtained through energy dissipative self-assembly of MT filaments at an air-buffer interface. The MT rings exhibit autonomous oscillation manifested through periodic changes in the size and shape. We propose the oscillation of the MT rings is attributed to mechanical feedback arising from accumulated stress induced by the driving force of the motor protein system. This work might offer new insights to our current understanding on the mechanical feedback driven oscillation of organized structures and its effect on dynamic processes in living systems.