Two-photon absorbing block copolymer as a nanocarrier for porphyrin: Energy transfer and singlet oxygen generation in micellar aqueous solution
Two-photon absorbing block copolymer as a nanocarrier for porphyrin: Energy transfer and singlet oxygen generation in micellar aqueous solution
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DOI：
10.1021/ja071057p
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发表时间：
2007-06-13
影响因子：
15
通讯作者：
Jen, Alex K. -Y.
中科院分区：
文献类型：
--
作者：
Chen, Ching-Yi;Tian, Yanqing;Jen, Alex K. -Y.
设计合成了一种新型的两亲性水溶性2PA-生色团嵌段共聚物。用嵌段共聚物在水溶液中生成了胶束(纳米结构)，并用动态光散射(DLS)和原子力显微镜(AFM)对其进行了表征。我们证明了疏水性的卟啉可以在胶束的辅助下被结合到水溶液中。差示扫描量热法(DLS)结果表明，产物的平均直径在59-77 nm之间。在胶束水溶液中，即使供体和受体没有共价键合，也可以观察到高达96%的能量从2PA生色团转移到卟啉。此外，能量转移有助于从卟啉客体分子中有效地产生单线态氧(在800 nm处增加了2.6倍)。
A novel amphiphilic water-soluble 2PA-chromophore-containing block copolymer was designed and synthesized. Micelles (nanostructures) were generated in the aqueous solution using the block copolymer and characterized using dynamic light scattering (DLS) and atomic force microscopy (AFM). We demonstrated that hydrophobic porphyrin could be incorporated into aqueous solution with the assistance of micelles. The results from DLS showed that the average diameters are in the range of 59-77 nm. Efficient energy transfer (as high as 96%) from the 2PA chromophore to porphyrin was observed in micellar aqueous solution even though the donor and acceptor were not covalently bonded. Furthermore, the energy transfer contributes to the efficient generation of the singlet oxygen (by a factor of 2.6 at 800 nm) from the porphyrin guest molecules.