HTLV‐positive and ‐negative T‐cell lymphomas. Morphological and immunohistochemical differences between european and HTLV‐positive japanese T‐cell lymphomas
HTLV‐positive and ‐negative T‐cell lymphomas. Morphological and immunohistochemical differences between european and HTLV‐positive japanese T‐cell lymphomas
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HTLV 阳性和阴性 T 细胞淋巴瘤欧洲和 HTLV 阳性日本 T 细胞淋巴瘤的形态学和免疫组织化学差异。
DOI：
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发表时间：
1985
影响因子：
6.4
通讯作者：
E. Gödde‐Salz
中科院分区：
文献类型：
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作者：
Karl Lennet;M. Kikuchi;E. Sato;T. Suchi;A. Stansfeld;A. Feller;M. Hansmann;H. Müller;E. Gödde‐Salz
我们研究了56例恶性淋巴瘤的组织学和免疫组织化学特征，推测是外周T细胞起源。该研究的目的是确定病毒相关的T细胞淋巴瘤是否可以在形态学或免疫组织化学上与病毒阴性的T细胞淋巴瘤区分开来。这些病例来自日本、联合王国（包括4例加勒比地区病例）和德意志联邦共和国的地方性和非地方性地区。对所有日本和加勒比地区患者以及8名德国患者的血清进行成人T细胞白血病病毒相关抗原HTLV - A抗体检测。所有病例切片均由5名训练有素的组织病理学家进行盲检。在大多数情况下，低温切片可以从新鲜组织标本中制备，并用大量单克隆抗体染色。
A total of 56 cases of malignant lymphoma presumed to be of peripheral T‐cell origin were investigated with regard to histological and immunohistochemical features. The goal of the study was to determine whether virus‐associated T‐cell lymphomas can be morphologically or immunohistochemically distinguished from presumably virus‐negative T‐cell lymphomas. The cases came from endemic and nonendemic regions of Japan, the United Kingdom (including 4 Caribbean cases) and the Federal Republic of Germany. Sera of all Japanese and Caribbean patients and 8 German patients were tested for antibodies to adult T‐cell leukaemia virus‐associated antigen HTLV‐A. In all cases sections were examined blind by 5 welltrained histopathologists. In most cases cryostat sections could be prepared from fresh tissue specimens and stained with a large panel of monoclonal antibodies.