Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers
Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers
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DOI：
10.1200/jco.2006.06.7330
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发表时间：
2006-11-01
影响因子：
45.3
通讯作者：
Wiseman, Sam M.
中科院分区：
文献类型：
--
作者：
Griffith, Obi L.;Melck, Adrienne;Wiseman, Sam M.
研究目的：估计有4%-7%的人在一生中会出现具有临床意义的甲状腺结节。在许多情况下，术前穿刺活检的诊断是不确定的。因此，有一个明确的需要改进的诊断测试，以区分恶性和良性甲状腺肿瘤。高通量分子分析技术的最新发展应允许新的诊断标志物的快速评价。然而，研究人员正面临着大量的潜在标志物从众多的甲状腺癌表达profilingstudy.Materials和MethodsTo解决这一挑战，我们已经进行了全面的荟萃审查甲状腺癌的生物标志物从21发表的研究。一个基因排序系统，考虑了比较的数量一致，总样本数，平均倍数变化和方向的变化被designed.ResultsWe观察到，基因一致报道的多个研究在一个高度显着的比率（P
PurposeAn estimated 4% to 7% of the population will develop a clinically significant thyroid nodule during their lifetime. In many cases, preoperative diagnoses by needle biopsy are inconclusive. Thus, there is a clear need for improved diagnostic tests to distinguish malignant from benign thyroid tumors. The recent development of high-throughput molecular analytic techniques should allow the rapid evaluation of new diagnostic markers. However, researchers are faced with an overwhelming number of potential markers from numerous thyroid cancer expression profiling studies.Materials and MethodsTo address this challenge, we have carried out a comprehensive meta-review of thyroid cancer biomarkers from 21 published studies. A gene ranking system that considers the number of comparisons in agreement, total number of samples, average fold-change and direction of change was devised.ResultsWe have observed that genes are consistently reported by multiple studies at a highly significant rate ( P