A case series on common cold to severe bronchiolitis and pneumonia in children following human metapneumovirus infection in Sri Lanka.
A case series on common cold to severe bronchiolitis and pneumonia in children following human metapneumovirus infection in Sri Lanka.
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DOI：
10.1186/s13104-018-3239-3
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发表时间：
2018-02-14
影响因子：
1.8
通讯作者：
Rayes MLM
中科院分区：
文献类型：
--
作者：
Jayaweera JAAS;Noordeen F;Kothalaweala S;Pitchai FNN;Rayes MLM
斯里兰卡hMPV感染的流行率尚未报道，在这里，我们报告了一系列5岁以下儿童hMPV感染的病例。纳入了2013年3月至2014年8月期间来自阿努拉达普拉教学医院的阿尔蒂患者。对鼻咽抽吸物进行间接荧光试验，以鉴定呼吸道病毒[呼吸道合胞病毒（RSV）、副流感病毒1、2和3、甲型和B型流感病毒以及hMPV]。逆转录-聚合酶链反应进一步证实hMPV感染。在该病例系列中，hMPV感染表现出一系列呼吸道症状，从普通感冒到严重程度不同的危及生命的下呼吸道感染。在某些情况下，hMPV感染的临床表现与RSV引起的阿尔蒂相似。在某些阿尔蒂病例中也观察到hMPV与RSV的合并感染。与hMPV单一感染相比，通过剖宫产分娩且出生顺序> 3的儿童发生RSV合并感染的比值比为3.5和4.3（95% CI）。缺乏确定病毒病因的诊断设施，导致使用抗生素，这表明该国需要建立病毒诊断设施。本文的在线版本（10.1186/s13104-018-3239-3）包含补充材料，可供授权用户使用。
The prevalence of hMPV infections in Sri Lanka has not been reported and here we report a case series of hMPV infection in children less than 5 years. Patients with ARTI were included from Teaching Hospital, Anuradhapura from March 2013 to August 2014. Indirect fluorescence assay was performed on nasopharyngeal aspirates for the identification of respiratory viruses [respiratory syncytial virus (RSV), parainfluenza virus 1, 2 and 3, influenza A and B and hMPV]. Moreover, reverse transcriptase-polymerase chain reaction was done to further confirm the hMPV infection. In this case series, hMPV infection showed a range of respiratory symptoms from common cold to life threatening lower respiratory tract infections with varying severity. In some cases, the clinical presentation of hMPV infection was similar to the ARTI caused by RSV. hMPV co-infections with of RSV have also been seen in some cases of ARTI. A child delivered through cesarean section and birth order > 3 has an Odds ratio of 3.5 and 4.3 (95% CI) for developing co-infection with RSV compared to hMPV mono-infections. Lack of diagnostic facilities to identify the viral aetiology has contributed to the use of antibiotics indicating the need for establishing viral diagnostic facilities in the country. The online version of this article (10.1186/s13104-018-3239-3) contains supplementary material, which is available to authorized users.