Cytological identification of metastatic epithelial nephroblastoma in pleural fluid: report of a case and review of literature.
Cytological identification of metastatic epithelial nephroblastoma in pleural fluid: report of a case and review of literature.
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胸水中转移性上皮性肾母细胞瘤的细胞学鉴定：一例报道并文献复习。
DOI：
10.1002/dc.20535
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发表时间：
2006
影响因子：
1.3
通讯作者：
Filie,ArmandoC
中科院分区：
文献类型：
--
作者：
Schinstine,Malcolm;Abati,Andrea;Tsokos,Maria;Fox,Elizabeth;Filie,ArmandoC
肾母细胞瘤（肾母细胞瘤）是最常见的儿童肾脏肿瘤，通常表现为组织学和细胞学上由胚基细胞、上皮细胞和间质细胞组成。积液并不少见，当含有间变性肿瘤细胞时，可能提示预后不良。在本病例中，我们报告的细胞学外观的肾母细胞瘤转移到胸膜。积液主要由显示上皮分化的肿瘤细胞组成。肿瘤细胞大多呈现为炎症背景下的三维聚集体。许多囊性和管状结构被确定。肿瘤细胞显示出强的CD 56和WT 1免疫反应性。随后的手术标本的组织学反映了细胞学中看到的特征。细胞病理学诊断。2006;34：621-625.© 2006 Wiley-Liss公司。
Nephroblastoma (Wilms' tumor) is the most common childhood renal tumor and usually presents with a histology and cytology consisting of blastemal, epithelial, and stromal cells. Effusions are not uncommon and may suggest an unfavorable prognosis when containing anaplastic tumor cells. In the present case, we report the cytological appearance of a Wilms' tumor metastatic to the pleura. The effusion consisted primarily of tumor cells demonstrating epithelial differentiation. The tumor cells mostly presented as three‐dimensional aggregates in an inflammatory background. Many cystic and tubular structures were identified. The tumor cells demonstrated strong CD56 and WT1 immunoreactivity. The histology of a subsequent surgical specimen reflected the features seen in cytology. Diagn. Cytopathol. 2006;34:621–625. © 2006 Wiley–Liss, Inc.