Hot topic: Bovine leukemia virus (BLV)-infected cows with low proviral load are not a source of infection for BLV-free cattle
Hot topic: Bovine leukemia virus (BLV)-infected cows with low proviral load are not a source of infection for BLV-free cattle
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DOI：
10.3168/jds.2015-10480
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发表时间：
2016-06-01
影响因子：
3.5
通讯作者：
Esteban, Eduardo N.
中科院分区：
文献类型：
--
作者：
Juliarena, Marcela A.;Barrios, Clarisa N.;Esteban, Eduardo N.
牛白血病病毒（BLV）引起牛的白血病或淋巴瘤。虽然大多数BLV感染动物不会发病，但它们在畜群水平上维持BLV的传播链。作为控制病毒的可行方法，已提出选择携带BoLA-DRB 3 *0902等位基因的牛，因为该等位基因与BLV感染谱或低前病毒载量（LPL）表型密切相关。为了测试这些牛在自然条件下是否影响BLV传播链，将选择的BLV感染的LPL-BoLA-DRB 3 *0902杂合奶牛纳入BLV阴性奶牛群。在20个月的实验期间，每头BLV感染的奶牛平均保持5.4头（范围4.17-6.37）BLV阴性奶牛的比例，并且没有BLV阴性牛被感染。因此，该牛群中的BLV发病率为零，而不同当地牛群中的BLV发病率为0.06 - 0.17例/100牛日。这一发现强烈表明，LPL-BoLA-DRB 3 *0902牛在研究期间破坏了BLV传播链。
The bovine leukemia virus (BLV) causes leukemia or lymphoma in cattle. Although most BLV-infected animals do not develop the disease, they maintain the transmission chain of BLV at the herd level. As a feasible approach to control the virus, selection of cattle carrying the BoLA-DRB3*0902 allele has been proposed, as this allele is strongly associated with a BLV infection profile or the low proviral load (LPL) phenotype. To test whether these cattle affect the BLV transmission chain under natural conditions, selected BLV-infected LPL-BoLA-DRB3*0902 heterozygous cows were incorporated into a BLV-negative dairy herd. An average ratio of 5.4 (range 4.17-6.37) BLV-negative cows per BLV-infected cow was maintained during the 20 mo of the experiment, and no BLV-negative cattle became infected. The BLV incidence rate in this herd was thus zero, whereas BLV incidence rates in different local herds varied from 0.06 to 0.17 cases per 100 cattle-days. This finding strongly suggests that LPL-BoLA-DRB3*0902 cattle disrupted the BLV-transmission chain in the study period.