THE EFFECT OF NEUROTENSIN ON FOOD-CONSUMPTION IN THE RAT
THE EFFECT OF NEUROTENSIN ON FOOD-CONSUMPTION IN THE RAT
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DOI：
10.1016/0014-2999(82)90116-9
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发表时间：
1982-01-01
影响因子：
5
通讯作者：
PRANGE, AJ
中科院分区：
文献类型：
--
作者：
LUTTINGER, D;KING, RA;PRANGE, AJ
本文研究了神经降压素对大鼠摄食行为的影响。脑室内[I.C.V.]给予神经降压素(3.3-30微克)可引起24小时食物剥夺大鼠摄食量的剂量相关减少。急性丙型脑炎。在摄入一种新口味后不久注射神经降压素(30微克)，在48小时后的测试中没有产生味道厌恶，这表明低剂量中枢注射神经降压素减少食物摄入量与条件性味道厌恶无关。皮下注射TRH(2.2微克)。抑制食物摄取，并似乎略微减弱由10微克神经降压素引起的食物摄取抑制。
The effects of neurotensin on feeding behavior were studied in rats. Intracerebroventricular [i.c.v.] administration of neurotensin (3.3-30 .mu.g) produced a dose-related decrease in food intake in 24 h food deprived rats. Acute i.c.v. injection of neurotensin (30 .mu.g) shortly after the ingestion of a novel flavor did not produce a flavor aversion during testing 48 h later, suggesting that reduction of food intake by low doses of centrally administered neurotensin is not related to a conditioned taste aversion. TRH (2.2 .mu.g) administered i.c.v. inhibited food intake and appeared to slightly attenuate the inhibition of food intake induced by 10 .mu.g neurotensin.