Chronotropic response of isolated guinea pig atria to alterations in pCO2, bicarbonate, and pH.
Chronotropic response of isolated guinea pig atria to alterations in pCO2, bicarbonate, and pH.
复制标题
离体豚鼠心房对 pCO2、碳酸氢盐和 pH 值变化的变时性反应。
DOI：
--
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
A. Trzebski
中科院分区：
文献类型：
--
作者：
A. Berȩsewicz;A. Trzebski
用CO_2-HCO_3缓冲系统研究了呼吸和代谢改变细胞外pH值对豚鼠离体心房自发收缩率的影响。在6.8至8.25的范围内，收缩率随着pH值的增加而增加。呼吸和代谢的pH值的变化产生定量相似的变时性反应。然而，呼吸pH值的变化过程中的节奏变化的时间过程是显着更快。当灌注液pCO 2和碳酸氢盐同时提高在恒定的pH值，收缩率最初下降，然后返回到控制值。在返回到对照溶液时，收缩速率快速上升，随后缓慢返回到对照值。我们的结论是，变时性反应的酸碱变化介导的细胞内pH值的变化。
The effect of respiratory and metabolic alterations of extracellular pH on the rate of spontaneous contractions of isolated atria of guinea pig hearts was examined using a CO2HCO3 buffer system. The rate of contractions increased with the increase in pH in the range of 6.8 to 8.25. Respiratory and metabolic alterations of pH produced quantitatively similar chronotropic responses. However, time-course of rhythm change was significantly faster during respiratory alterations of pH. When perfusate pCO2 and bicarbonate were simultaneously raised at constant pH, the rate of contractions initially fell and then returned to the control value. On the return to control solution a rapid rise in the rate of contractions was followed by a slow return to the control value. We conclude that the chronotropic responses to acid-base alterations are mediated by changes in the intracellular pH.