Bone mineral density in feline mucopolysaccharidosis VI measured using dual-energy X-ray absorptiometry.
Bone mineral density in feline mucopolysaccharidosis VI measured using dual-energy X-ray absorptiometry.
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使用双能 X 射线吸收测定法测量猫粘多糖沉积症 VI 的骨矿物质密度。
DOI：
10.1007/bf00310257
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发表时间：
1995
影响因子：
4.2
通讯作者：
Thrall,MA
中科院分区：
文献类型：
--
作者：
Turner,AS;Norrdin,RW;Gaarde,S;Connally,HE;Thrall,MA
Dual-energy X-ray absorptiometry (DXA) was used to determine thein vivobone mineral density (BMD) and bone mineral content (BMC) of lumbar vertebrae in six cats affected with the inherited lysosomal storage disease mucopolysaccharidosis VI (MPS VI). DXA was also performed on MPS cats that had a bone marrow transplant (BMT) and total body irradiation (TBI) (MPS+BMT;n=7), normal cats that had a bone marrow transplant, and TBI (control+BMT; n=8) and normal cats (control; n=14). Following euthanasia, one of the lumbar vertebrae that had been scanned (L5) was harvested and bone volume (BV/TV%) was determined by histomorphometry. Thein vivoBMD and BMD measurements were compared with the BV/TV%. There was a greater BMD and BMC in the MPS+BMT cats compared with the MPS cats but the difference was not statistically significant. However, there was a greater BV/TV% in the MPS+BMT cats compared with the MPS cats and the difference was significant (P=0.0152). Correlation between the noninvasivein vivoDXA measurements of BMD and BMC and the BV/TV% was significant (r2=0.767,P<0.0001;r2=0.504,P<0.0001). Noninvasivein vivoDXA was a rapid and precise method for measuring the lumbar BMD and BMC in cats and it correlated well with histomorphometric determination of bone mass. Further, the response of inherited storage diseases such as MPS VI to therapy, such as BMT, could be monitored in a longitudinal fashion using DXA.
