Graded porous polyurethane foam: A potential scaffold for oro-maxillary bone regeneration
Graded porous polyurethane foam: A potential scaffold for oro-maxillary bone regeneration
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DOI：
10.1016/j.msec.2015.03.002
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发表时间：
2015-06-01
影响因子：
7.9
通讯作者：
Licoccia, S.
中科院分区：
文献类型：
--
作者：
Giannitelli, S. M.;Basoli, F.;Licoccia, S.
骨组织工程应用需要生物材料为细胞粘附、迁移和增殖提供基质，同时为构建体提供合适的机械性能。在本研究中，合成了聚氨酯（PU）泡沫，以开发一种具有致密壳和多孔芯特征的分级多孔材料，用于治疗口腔乳头骨缺损。泡沫是通过一锅反应从多异氰酸酯和生物相容性聚酯二醇开始合成的，使用水作为发泡剂。研究了不同的发泡条件，目的是创造一种致密/多孔的功能梯度材料，该材料可以同时作为骨缺损再生的骨传导支架和牙龈组织向内生长的膜屏障。对所得 PU 的形态和机械性能进行了表征。与骨髓来源的人间充质基质细胞（hBMSC）结合进行生物相容性评估。我们的研究结果证实，该材料可能适合引导骨再生应用。 (C) 2015 Elsevier B.V. 保留所有权利。
Bone tissue engineering applications demand for biomaterials offering a substrate for cell adhesion, migration, and proliferation, while inferring suitable mechanical properties to the construct. In the present study, polyurethane (PU) foams were synthesized to develop a graded porous material characterized by a dense shell and a porous core-for the treatment of oro-makillary bone defects. Foam was synthesized via a one-pot reaction starting from a polyisocyanate and a biocompatible polyester diol, using water as a foaming agent. Different foaming conditions were examined, with the aim of creating a dense/porous functional graded material that would perform at the same time as an osteoconductive scaffold for bone defect regeneration and as a membrane-barrier to gingival tissue ingrowth. The obtained PU was characterized in terms of morphological and mechanical properties. Biocompatibility assessment was performed in combination with bone-marrow-derived human mesenchymal stromal cells (hBMSCs). Our findings confirm that the material is potentially suitable for guided bone regeneration applications. (C) 2015 Elsevier B.V. All rights reserved.