IL-10: A Multifunctional Cytokine in Viral Infections.
IL-10: A Multifunctional Cytokine in Viral Infections.
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DOI：
10.1155/2017/6104054
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发表时间：
2017
影响因子：
4.1
通讯作者：
Sevilla N
中科院分区：
文献类型：
--
作者：
Rojas JM;Avia M;Martín V;Sevilla N
抗炎主调节因子IL-10对于在免疫应答的急性期保护宿主免受组织损伤至关重要。这种调节机制是T细胞稳态的核心，可以被病毒劫持以逃避免疫。IL-10可以由几乎所有的免疫细胞产生，并且它还可以调节这些细胞的功能。因此，了解这种多功能细胞因子的作用是一项复杂的任务。在本综述中，我们讨论了驱动IL-10的生产和细胞来源的细胞因子在抗病毒免疫反应的因素。我们特别关注影响抗病毒免疫应答的IL-10调节机制，以及病毒如何利用这一中心调节途径来逃避免疫并建立慢性/潜伏感染。
The anti-inflammatory master regulator IL-10 is critical to protect the host from tissue damage during acute phases of immune responses. This regulatory mechanism, central to T cell homeostasis, can be hijacked by viruses to evade immunity. IL-10 can be produced by virtually all immune cells, and it can also modulate the function of these cells. Understanding the effects of this multifunctional cytokine is therefore a complex task. In the present review we discuss the factors driving IL-10 production and the cellular sources of the cytokine during antiviral immune responses. We particularly focus on the IL-10 regulatory mechanisms that impact antiviral immune responses and how viruses can use this central regulatory pathway to evade immunity and establish chronic/latent infections.