Inhaled nitric oxide use in preterm infants in California neonatal intensive care units
Inhaled nitric oxide use in preterm infants in California neonatal intensive care units
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DOI：
10.1038/jp.2016.49
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发表时间：
2016-08-01
影响因子：
2.9
通讯作者：
Lee, H. C.
中科院分区：
文献类型：
--
作者：
Handley, S. C.;Steinhorn, R. H.;Lee, H. C.
目的：描述早产儿吸入一氧化氮（iNO）暴露和新生儿重症监护室（NICU）使用的变化。研究设计：这是一项回顾性队列研究，研究对象为2005年至2013年期间胎龄为22至33+ 6/7周（GA）的婴儿。按GA进行分层分析，包括人群特征、iNO使用随时间的变化和医院variation.Results：在65824例婴儿中，1718例（2.61%）接受了iNO。婴儿，22至24+ 6/7周的GA，具有最高的iNO暴露发生率（6.54%）。社区NICU（n=77，中位医院使用率0.7%）使用的iNO少于区域NICU（n=23，中位医院使用率5.8%）。在22至24+ 6/7周的GA婴儿中，区域中心的中位率为10.6%（医院四分位数范围为3.8%至22.6%）。结论：iNO暴露量随GA和医院水平而变化，最多用于极早产儿和区域中心。差异反映了对早产儿适当使用iNO缺乏共识。
OBJECTIVE: To describe inhaled nitric oxide (iNO) exposure in preterm infants and variation in neonatal intensive care unit (NICU) use.STUDY DESIGN: This was a retrospective cohort study of infants, 22 to 33+ 6/7 weeks of gestational age (GA), during 2005 to 2013. Analyses were stratified by GA and included population characteristics, iNO use over time and hospital variation.RESULTS: Of the 65 824 infants, 1718 (2.61%) received iNO. Infants, 22 to 24+ 6/7 weeks of GA, had the highest incidence of iNO exposure (6.54%). Community NICUs (n=77, median hospital use rate 0.7%) used less iNO than regional NICUs (n=23, median hospital use rate 5.8%). In 22 to 24+ 6/7 weeks of GA infants, the median rate in regional centers was 10.6% (hospital interquartile range 3.8% to 22.6%).CONCLUSION: iNO exposure varied with GA and hospital level, with the most use in extremely premature infants and regional centers. Variation reflects a lack of consensus regarding the appropriate use of iNO for preterm infants.