Human platelet stimulation by acetyl glyceryl ether phosphorylcholine.
Human platelet stimulation by acetyl glyceryl ether phosphorylcholine.
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乙酰甘油醚磷酸胆碱刺激人血小板。
DOI：
10.1172/jci110108
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Pinckard,RN
中科院分区：
文献类型：
--
作者：
McManus,LM;Hanahan,DJ;Pinckard,RN
乙酰甘油醚磷酸胆碱（AGEPC）诱导柠檬酸化人富血小板血浆中剂量依赖性血小板聚集和[3 H] 5-羟色胺和血小板因子4释放。ADP清除剂或吲哚美辛防止不可逆的血小板聚集反应诱导的0.2 μ M AGEPC，但对血小板分泌没有影响;前列环素抑制AGEPC诱导的聚集和分泌。EDTA或EGTA抑制AGEPC诱导的聚集，但对血小板分泌没有影响。
Acetyl glyceryl ether phosphorylcholine (AGEPC) induced dose-dependent platelet aggregation and release of [3H]serotonin and platelet factor 4 in citrated human platelet-rich plasma. ADP scavengers or indomethacin prevented irreversible platelet aggregation responses induced by 0.2 microM AGEPC but had no effect upon platelet secretion; prostacyclin inhibited AGEPC-induced aggregation and secretion. EDTA or EGTA inhibited AGEPC-induced aggregation but had no effect on platelet secretion.